Examples: Β-lactam antibiotics (inhibit peptidoglycan synthesis) Penicillin cephalosporin Sulfonamide drugs (aka sulfa drugs) (inhibit folic acid synthesis) Sulfadiazine Sulfadimethoxine Sulfamoxole
Examples: Heavy metals (bind with S atoms in the enzyme) mercury (merthiolate, thimerosal) lead silver
H+ H e- NADH Reduction Oxidation H H NAD+ H
H+ H e- NADH NAD in its reduced state (NADH) NAD+ NAD in its oxidized state (NAD+)
FADH2 H FAD in its reduced state (FADH2) FAD FAD in its oxidized state (FAD)
High energy bonds P P P adenine Phosphate groups ribose Structure of ATP
P P P ATP 7 Kcal of energy P P P ADP + P
ATP energy ADP + P energy phosphorylation
NADH energy NADH ATP NAD+ NAD+ ADP + P energy Energy transfers