Experimental design and power analysis for systems biology Karlyn Beer 21 Aug 2012.

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Presentation transcript:

Experimental design and power analysis for systems biology Karlyn Beer 21 Aug 2012

Do your research before you do your research

Statistical power Power = The probability of detecting an effect, given that the effect is really there.

Statistical power

Power and Sample size

Effect size (d) Δ Mean 1 Mean 2 How to calculate a pooled SD:

Power, sample size and effect size (d)

1. Is miRNA expression associated with glioblastoma cases? Compare mean miRNA expression in glioblastoma case patients with non-GB controls Use a 2 sample t test We’ll explore how to handle different group sizes and a non-ideal dataset (not uncommon to have one..)

2. Is miRNA expression correlated with copy number in glioblastoma cases?