Principles of Structure Dr. Helen Berman September 11, 2002.

Slides:

Advertisements

Similar presentations

PHAR201 Lecture Principles of DNA and RNA Structure PHAR 201/Bioinformatics I Philip E. Bourne Department of Pharmacology, UCSD Prerequisite Reading:

Advertisements

Organic Chemistry Second Edition Chapter 5 David Klein Stereoisomerism

Essential Biochemistry by Pratt & Cornely, © 2004 John Wiley & Sons, Inc. Figure 9.01 Catabolism and anabolism.

Essential Biochemistry by Pratt & Cornely, © 2004 John Wiley & Sons, Inc. Figure Glucose metabolism in context.

Essential Biochemistry by Pratt & Cornely, © 2004 John Wiley & Sons, Inc.

Essential Biochemistry by Pratt & Cornely, © 2004 John Wiley & Sons, Inc. Figure Cellular locations of major metabolic pathways.

Fischer convention for assigning the enantiomers of glyceraldehyde.

Office hours T 1-2, W 12-1:30, R 2-3. Prokaryotic Transcription.

Figure 6.04 Effect of a catalyst on a chemical reaction.

constitutional isomers:

The Nature of Matter Water and solutions Carbohydrates and Lipids Nucleic Acids and Proteins Energy and Reactions

Carbohydrates What are they? –Sugars, starches & much more –Most abundant molecules on Earth –End products of photosynthesis.

Fundamentals of Biochemistry

There are three scholarships for pre-medical students that are available for the academic year. These are: Whatcom County Medical Society Scholarship:

1 Stereoisomers Review: –Structural Isomers: Compounds that have the same molecular formula, but differ in the structural arrangement of atoms. Examples:

Lecture 1. Introduction about Biochemistry Biochemistry :- (from Greek : βίος, bios, "life") is the study of the chemical processes in living organisms.

Week 1, Quiz 3 – Are you ready?. 1. Is less dense than water. 2. Is a polar substance. 3. Is more dense than water. 4. Is a nonpolar substance. Countdown.

Copyright © John Wiley & Sons, Inc. All rights reserved.  When DNA is transcribed, the result is an RNA molecule.  RNA is then translated into a sequence.

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.1 Chapter 19 Amino Acids and Proteins 19.1 Proteins and Amino Acids.

Biochemistry Notes. Elements and Atoms Matter is anything that has mass and takes up space. Atoms are the basic building blocks of all matter. Elements.

Warm up 10/2:Warm up 10/2: 1.Pass labs toward the center. 2.When is the next Exam? a.When is the study guide due? b.When is intervention? 3.When is your.

Molecular Biology (Foundation Block) The central dogma of molecular biology Nucleotide chemistry DNA, RNA and chromosome structure DNA replication Gene.

Fundamentals of Biochemistry Third Edition Fundamentals of Biochemistry Third Edition Chapter 11 Enzymatic Catalysis Chapter 11 Enzymatic Catalysis Copyright.

CHAPTER 2 BASIC CHEMISTRY

BIOCHEMISTRY pp CARBON COMPOUNDS CARBON BONDING Has 4 electrons in the outer level so it can bond 4 times Has 4 electrons in the outer level so.

Proteins & DNA. Amino Acids: the building blocks of Proteins.

Molecular Biology I-II The central dogma of molecular biology Nucleotide chemistry DNA, RNA and Chromosome Structure DNA Replication Gene Expression Transcription.

DNA Structures Dr. Helen Berman September 18, 2002.

Fundamentals of Biochemistry Third Edition Fundamentals of Biochemistry Third Edition Chapter 8 Carbohydrates Chapter 8 Carbohydrates Copyright © 2008.

Protein Structure (Foundation Block) What are proteins? Four levels of structure (primary, secondary, tertiary, quaternary) Protein folding and stability.

Molecular Biophysics Lecture 2 Protein Structure II BCHS 6297 Lecturers held Tuesday and Thursday 10 AM – 12 Noon 402B-HSC.

Focus What property of water is this picture demonstrating and how.

CHAPTER 10 DATA COLLECTION METHODS. FROM CHAPTER 10 Copyright © 2003 John Wiley & Sons, Inc. Sekaran/RESEARCH 4E.

Chapter 3 Review Chemistry of Life. Atoms The smallest unit of matter that cannot be broken down by chemical means.

Fundamentals of Biochemistry Third Edition Fundamentals of Biochemistry Third Edition Chapter 4 Amino Acids Chapter 4 Amino Acids Copyright © 2008 by John.

Biochemistry 2-3 CARBON COMPOUNDS. Chemistry of carbon  4 valence electrons  (highly bondable!)  Carbon can bond with carbon and form long chains 

Fundamentals of Biochemistry

LEHNINGER PRINCIPLES OF BIOCHEMISTRY

Fundamentals of Biochemistry

Fundamentals of Biochemistry Third Edition Fundamentals of Biochemistry Third Edition Chapter 5 Proteins: Primary Structure Chapter 5 Proteins: Primary.

5.7 Fischer Projections Fischer projections can also be used to represent molecules with chirality centers Horizontal lines represent attachments coming.

Figure 1.1. Cellular organization of prokaryotic and eukaryotic cells. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin.

Water Basics Polar: part of the molecule is slightly positive… other part slightly negative – Oxygen (-) – Hydrogen (+) Hydrogen Bond: Positive Hydrogen.

9.4 Hydration The components of water (-H and –OH) are added across a C=C double bond The acid catalyst is often shown over the arrow, because it is regenerated.

Molecular Biology - I Dr. Sumbul Fatma Clinical Chemistry Unit Department of Pathology.

Fundamentals of Biochemistry Third Edition Fundamentals of Biochemistry Third Edition Chapter 4 Amino Acids Chapter 4 Amino Acids Copyright © 2008 by John.

Exploring Nucleic Acid Structures

Reference books Fundamentals of Biochemistry, by Voet D., Voet JG, and Pratt CW, John Wiley & Sons, Inc (1999). Lehninger Principles of Biochemistry, 5th.

Fundamentals of Biochemistry

Fundamentals of Biochemistry

Fundamentals of Biochemistry

Macromolecules/ Properties of Water

Lecture 5 Organic Compounds

Biochemistry Carbon => life.

INTRODUCTION Biochemistry

Figure 2.1 Central Dogma of molecular biology.

Fundamentals of Biochemistry

BIOCHEMISTRY Water – inorganic (not living) chemical formula is H2O

Macromolecule Review.

Biological Molecules -Biological molecules consist primarily of carbon, oxygen, hydrogen, and nitrogen. -These elements share valence electrons to form.

Proteins: Secondary Structure Alpha Helix

1. Perspective Formulas.

Fischer Projections Section 5.7.

Biochemistry Booklet Instructions 2016

Fundamentals of Biochemistry

Fundamentals of Biochemistry

Stereochemistry.

Bell Ringer Describe what an enzyme is..

Biochemistry Basics.

Hydration Mechanism Section 9.4.

Presentation transcript:

Principles of Structure Dr. Helen Berman September 11, 2002

CONFIGURATION To go from  to  a bond is broken REPRESENTATION Ball and stick Haworth Fischer Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 249.

Fischer Projections Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 68.

Haworth Projection Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 248.

Stereoisomers n chiral centers yield 2 n stereoisomers Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 69.

Amino Acids “corn crib” Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 68.

D sugars Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 248.

Torsion Angles Dihedral Angles Saenger, Wolfram. Principles of Nucleic Acid Structure. Springer-Verlag New York Inc., 1984, p. 15.

Klyne Prelog Other nomenclatures Saenger, Wolfram. Principles of Nucleic Acid Structure. Springer-Verlag New York Inc., 1984, p. 16.

Newman Projection Creighton, Thomas. Proteins: Structures and Molecular Principles. W. H. Freeman and Company, 1984, p. 160.

Cyclohexanes Pyranose sugars Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, pp

Water Structure Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 30.

Water hydrogen bonding Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 30.

Ice structure Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 31.

Hydration of ions Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 32.

Hydration of polar groups Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 33.

Clathrate hydrates Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 179.

Clathrate hydrates Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 179.