CONTROL STRATEGY OF FMD IN LIBYA AND POST-VACCINATION MONITORING Dr. Ibrahim Eldaghayes Faculty of Veterinary Medicine University of Tripoli Tripoli, Libya.

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Presentation transcript:

CONTROL STRATEGY OF FMD IN LIBYA AND POST-VACCINATION MONITORING Dr. Ibrahim Eldaghayes Faculty of Veterinary Medicine University of Tripoli Tripoli, Libya Abdunaser Dayhum; Abdulwahab Kammon; Monier Sharif; Giancarlo Ferrari; Keith Sumption; Donald King; Santina Grazioli and Emiliana Brocchi

Libya GFRA Meeting October 20152

History of FMD in Libya: SerotypeYears FMDV-O:1959, 1962, , 1972, , , 1994, FMDV-A:1979, 2009 FMDV-C:0000 FMDV-Asia 1:0000 FMDV-SAT 1:0000 FMDV-SAT 2:2003, 2012 FMDV-SAT 3:0000 Source: GFRA Meeting October 20153

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Genotyping GFRA Meeting October 20155

EuFMD Real-Time Training Course in Kenya (Jan 2013) GFRA Meeting October 20156

Real-Time Training Course Lectures in Libya GFRA Meeting October 20157

FMD Scientific Day Tripoli, 30/03/2014 GFRA Meeting October 20158

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GFRA Meeting October Rapid Response Teams (RRT)

FMD lateral-flow devices: received from EuFMD GFRA Meeting October

GFRA Meeting October

The Progressive Control Pathway for FMD control GFRA Meeting October

Progressive Control Pathway (PCP) and Risk Based Strategic Plan implementation: Component 2.3 of EuFMD workplan (REMESA): Assist national FMD risk management as part of the REMESA action plan. WeekDate Week /01/2014 Week /03/2014 Week 3Postponed due to security reasons Week 4Postponed due to security reasons GFRA Meeting October

GFRA Meeting October

GFRA Meeting October

GFRA Meeting October

GFRA Meeting October

GFRA Meeting October

Mass Vaccination Campaign in Libya Sheep, Goats and Cattle: A & O Merial Vaccine Strains: O Manisa – O 3039 ; A Iran 05; (SAT-2 in 2012) Killed and purified vaccine 250 Vaccination Teams Once per year (2012 & 2013) 2014: Small ruminant once/year Cattle twice/year GFRA Meeting October

Vaccine Matching GFRA Meeting October

Agreement between the Libyan government and IZSLER, Italy 2012 GFRA Meeting October 2015

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GFRA Meeting October

GFRA Meeting October

 Component 1 investigations in FMD suspected outbreaks.  Component 2 focused on the immune response of vaccinated animals.  Component 3 focused on serology as a mean to investigate on the level of FMD virus circulation (anti-NSP antibodies) and on the serotypes present (anti-SP serotype-specific antibodies). GFRA Meeting October

Component 1 (FMD suspected outbreaks – Clinical cases) GFRA Meeting October

COMPONENT 2 (immune response in vaccinated animals) This component has addressed the immune response of vaccinated animals. The outcome to be measured will be the level of antibodies before the vaccine is injected and the level of antibodies after 30 days from the date of vaccination. The animals (Cattle and small ruminants) selected for sampling were ear-tagged and blood samples were collected at the day of vaccination and repeated after 30 days. GFRA Meeting October

GFRA Meeting October

Component 2: Immune response in vaccinated animals Sampling and testing criteria Anti-NSP Ab and titration of SP Abs (serotypes O, A, SAT2)  before and 30 days PV For each species (goat, sheep, cattle): 150 animals, 6-12 month- old, ear-tagged Possibly, 10 different owners for each species (15 animals for each owner) GFRA Meeting October

Immune response to vaccine in small ruminants farms 7 FARMS Vaccine: type O+A ≈ 30 animals/farm 6 farms NSP-NEG 1 farm NSP-POS GFRA Meeting October

Immune response to vaccine in small ruminants 6 FARMS NSP neg Vaccine: type O+A ≈ 30 animals/farm SEROCONVERSION 30 DPV Serotype O 135/164 (82%) Serotype A 152/164 (93%) GFRA Meeting October

Immune response to vaccine in 1 cattle farm Seroconversion 30 DPV OASAT 2 N +30/30 29/30 % +100 % 97 % Vaccine: types O+A+SAT2 30 cattle, NSP neg GFRA Meeting October

Current work Jan 2015 – Jan 2016 Cattle: Collection of serum from unvaccinated animals at the time of injection of the vaccine (time 0) and tag the animals from which the sample has been collected (n=99). Collect serum after 2, 4 and 6 months. Booster vaccination at 6 months for 70 animals. Collect serum again after 2, 4 and 6 months. GFRA Meeting October

EuFMD Team (March 2015) GFRA Meeting October

 Thanks to: EuFMD IZSLER, Brescia and Ministry of Health, Italian Government FAO OIE REMESA Pirbright Lab GFRA Meeting October

GFRA Meeting October