TDR Target Diseases: Malaria Schistosomiasis African Sleeping Sickness Chagas Disease Lymphatic filariasis Onchocerciasis Leishmaniasis Leprosy Tuberculosis Dengue Fever Objectives: CONTROL OF THE TROPICAL DISEASES (Diagnosis, Vaccine and Drug Development) RESEARCH STRENGTHENING (Training and Support to Institutions)

RCS Plus US$ 40-50,000/year US$ 10-15,000/year

Chose the Committee where the proposal will be submitted Respect deadlines for submission of proposals Carefully read the instructions Two copies of the proposal

CONFIDENTIAL INFORMATION Evaluation points: Originality Relevance to disease control Potential value to the field Capacity building component Adequacy of design methods

PROPOSAL Attractive to the readers/reviewers Direct Simple sentences Short TITLE Leave to the end Maximum 120 characters Name of the parasite or disease No abrreviations

FOUR TOTAL PAGES 1. Objectives and Rationale Clear objectives (Not too many )OR Hypotheses to be tested OR Questions to be answered Remember the priorities of the scientific committee (IMPROVEMENT OF DISEAES CONTROL) Presentation of the problem State the present status of knowledge Brief survey of relevant literature Outline or illustrate preliminary results

2. Experimental Design and Methods Methodology (General description with no details) Statistical methods Number of samples to be studied Chronogram (estimated duration of the each step) 3. Ethical considerations (If necessary) 4. Critical Assessments of the taken approach Possible limitations in reaching the objectives 5. References

Leave to the end 100 words Indicate the objectives WhyWhy the project should be undertaken rather than what is to be done Principal Investigator Legal Entity Institute, University, Ministry

BUDGET DETAILS List, funds requested and justification Personnel (ONLY RESEARCH PERSONNEL) 1- Principal InvestigatorNO SALARY 2,3,4- Co-investigators SALARY ALLOWED 5,6- Trainees/fellows Supplies laboratory reagents, glassware, plastics, sofwares Equipment minor equipments (US$ 1,000); major equipment (>US$ 1,000) Animals; Patient Costs Travel - local transportation; field research; NO ATTENDANCE AT SCIENTIFIC MEETINGS THE BUDGET MUST BE SIGNED BY THE PI AND THE CHIEF OF THE FINANCIAL OFFICE

PROJECT LINKS AND TRAINING OPPORTUNITIES 1- Collaboration with other Scientits and Research Institutions Give the names and institutional affiliations Indicate the need for such collaboration ATTACH LETTERS OF CONFIRMATION ATTACH CVs 2- Links with other TDR research projects (if any).

CURRICULUM VITAE (one page for EACH investigator) Name address, etc Degrees (subject, university, year) Posts hels (type of post, Institution, year) Publications (LIST FIVE PUBLICATIONS OVER THE LAST FIVE YEARS RELATED TO THE SUBJECT OF THE PROPOSAL)

ANNUAL PROGRESS REPORT Official forms No space limitations Essential for continued financial support FINAL REPORT Official forms No space limitations Essential for future support to other proposals FINANCIAL REPORTS Signed by the PI and the Institution Chief Financial Officer