Liver Cancer A leading cause of death in the world Can be primary or a metastatic site Seen more in other parts of the world incidence African American males 40 – 60 years old Cirrhosis Hepatitis B and C
Causes of Liver Cancer Primary Trauma Nutritional deficits Carcinogens Hepatotoxins Aspergillus fungus
Causes of Liver Cancer Metastatic Disease Due to the vascularity of the liver Esophagus Stomach Colon and rectum Breasts Lungs Malignant melanoma
Early Signs and Symptoms RUQ pain Abdominal tenderness Fatigue, malaise Anorexia Weight loss
Diagnostic Data Nuclear scan Determines structural changes Ultrasound guided liver biopsy Confirms malignancy
Late Signs and Symptoms Looks like cirrhosis Jaundice Ascites Bleeding disorders Encephalopathy
Treatment Surgical Only for single lesion in one lobe Resection of the lobe Cryoablation Freezing of tumors with liquid nitrogen Chemotherapy With intravascular infusion pump
Prognosis Usually fatal within 6 months Single lesion lobectomies can survive up to 5 years