The financial support of the European Commission is gratefully acknowledged. Material in this presentation reflects only the author’s views and the Commission is not liable for any use that may be made of the information contained herein. Siegfried Benkner Institute of Scientific Computing University of Vienna, Austria for the Aneurist Consortium October 5, 2007

@neurISTCopyright © EU ( ) IST Development of a generic IT infrastructure for the management and processing of heterogeneous data associated with the diagnosis and treatment of cerebral aneurysms and subarachnoid haemorrhage. Integrated Application - personalised risk – virtual endovascular treatment planning & stent - linking genetics to - modeling, simulation & visualization of multimodal service-oriented Grid infrastructure on-demand simulation and analysis services (semantic) data-integration services handling multi-scale, multi-modal information at distributed sites.

@neurISTCopyright © Integrative Application Suites Gen data Personal data @neuFuse Genetic risk Epidemiology knowledge Patient Pharma treatment Modelling, simulation and analysis services Modelling, simulation and analysis services

@neurISTCopyright © 2007 Grid Infrastructure Storage Resources BioISFiles Databases Compute Resources AnalysisSimulation Modeling Grid Layer (GEMSS2 / InnerGrid) OGSA-DAI GDMS Data Transfer Job Client Multimodal data Virtual endovascular treatment Linking genetics to Integrative rupture risk Controller Application Layer Resource Layer Middleware Layer Grid Middleware: GEMSS2, InnerGrid; Standard Web Services (WS-I) Data Integration: OGSA-DAI – WS-DAI; DQP; SQL Semantics: OWL, SPARQL

@neurISTCopyright © Data Integration Approach Semantic Data Mediation Federation of Services CRIM, Ontology Security, Pseudonymization, … Hospital information systems Sheffield, Geneva, Rotterdam,… EHR, PACS, … Public databases Genetic: EBI,NCBI Literature: Medline, etc. Product design databases COTS stents, coils, etc. Applications Users PACS PUBMED PACS Data Service OGSA/DAI GDMS Data Service OGSA/DAI GDMS Data Service OGSA/DAI GDMS PDD EHR

@neurISTCopyright © Clinical Reference Information Model (CRIM) Defines all information to be captured for a patient clinical information (imaging, diagnostic and treatment data, …) administrative information research results produced (indicators) Biomedical data infostructure Two different architectures (see next slide) Research ContextTreatment context Federated Biomedical Info Structure Data Capturing Imaging data Patient record Application Suites Processing & Analysis Distributed queries Knowledge discovery Denormalization Re-identification Normalization De-identification Information aquisition & structuring Information access, analysis & enrichment

@neurISTCopyright © Geneva (OTF) Sheffield (ANO) anoDB XML/DICOM files Files WS with SQL query XML WS with SQL query XML Hospital Intranet Data forms EHR PACS IDDB PACS EHR Acquisition tool IDDB Service Service FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWAL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL Push mechanism University network/DMZ Service Internet Data Acquisition Data Storage Data Access Hospital Intranet Hospital DMZ Logging Filtering Logging Filtering DICOM HL7 SQL DVD FTP HTTP/XML

@neurISTCopyright © 2007 Ontology Global conceptual schema of the disease Conceptual space Clinical Medicine Molecular Biology Epidemiology Simulation Disease Risk factor Incorporating “approved” existing ontologies FMA - Foundational Model of Anatomy GO - Gene Ontology DOLCE as Upper Ontology Concepts are mapped to Unified Medical Language System (UMLS) OWL-DL Lead partner: University of Freiburg ClassesRelationship Types DefinitionsUMLS Map

@neurISTCopyright © GDMS DAS Semantic Data Integration Schema Virtual Schema Mapping Data Access Services Data Mediation Services Ontology OGSA-DAI annotation

@neurISTCopyright © Pseudonymisation Service End-to-end security Attribute-based access control (ABAC) Certificate and Registration Authorities; Federated VO model Security Token Service Logging, Filtering Services Auditing Provenance built on top of Web services security Security Architecture

@neurISTCopyright © Contact Project co-ordinator: Universitat Pompeu Fabra Contact person: Dr.Alejandro Frangi Tel: Fax: WWW: