Cystic Fibrosis Ventura Simmons 1/29/2010 Period: 6/7

Summary Cystic Fibrosis mainly affects 2 of our many systems: -Respiratory, and -Digestive In these systems our airways, lungs (respiratory), stomach, colon, and intestines (digestive) These organs are affected by this disease because Cystic Fibrosis causes a change in the properties of the mucus that coats the inside of these organs, and this mucus aids the organs in surviving without it it’d be a lot like a teenager without electronics.

Chromosome 7

Recessive This Disease is Autosomal Recessive meaning you need to get the gene from both parents to obtain it fully just like blue eyes you need a blue eye gene from both parents to have blue eyes so if both parents have blue eyes you will just like if both parents have Cystic Fibrosis their child will. The opposite of recessive, dominant is GOOD,but if you have one dominant than you have 1 contaminated allele a.k.a your in trouble. In Autosomal Recessive the word Autosomal refers to the gene dealing with and autosome which is a cell that isn't a sex cell and autosome deals with sex cells but it is a somatic cell.

Allele Definition: An allele is an alternative form of a gene (one member of a pair) that is located at a specific position on a specific chromosome. C- For my slide show this will be considered the recessive allele which mean that if a child has this as one of its two alleles then they will most definitely carry the disease weather it is fully or half way. F- I used a F for my dominant allele and if u have two dominant that is good because then you are completely healthy but only one wont cut it. So the more F’s the better. FF would be homozygous dominant meaning 2 of the same dominant FC is heterozygous dominant meaning 1 dominant and 1 recessive Lastly CC which is homozygous recessive meaning it has 2 of the same recessive alleles.

homozygous dominant heterozygous dominant homozygous recessive Punnett Squares FC FFFFC C CC CC FFC CCC CC FFC F

Punnett Square Ratios Percentages 1:2 : 1 1FF: 2FC : 1CC 25% : 50% :25% 25%FF : 50%FC : 25%CC homozygous dominant : heterozygous dominant : homozygous recessive FC FFFFC C CC

Pheno and Genotype The F is the dominant allele and C is the recessive allele Phenotype CC= carrier and victim FC= just carrier FF= completely healthy Genotype FF= Homozygous dominant FC= Heterozygous dominant CC= homozygous recessive FC FFFFC C CC

Phenotype Genotype Explain Genotype and Phenotype probability using: Phenotype -Ratios- 3 : 1 - Percentages- 75% : 25% Phenotype deals with which possibilities have the dominant alleles against the ones that don’t have any dominant alleles Genotype - Ratios- 1FF : 2 FC : 1 CC - Percentages- 25% FF: 50% FC : 25%CC Genotype shows the probably for ALL the allele combo’s so FF, FC, and CC would all be classified separately. FC FFFFC C CC

Student Practice Genotype: Ratio: 3:1 Percentage: 75% yes 25% no Phenotype: Ratio: 1:2:1 Percentage: 25% NO 50% carrier 25% YES FF F F C FC C CC

Pedigree Square: MaleCircle: Female Orange: Full on diseaseHalf: Only Carrier Blue: No disease at all

Student Practice Square: MaleCircle: Female Orange: Full on disease Half: Only Carrier Blue: No disease at all 1.What 2 other possibilities of children could the first couple have? 2. What kind of husband would the center circle have to marry to have a healthy son. 3. If the first mother had a child with her son in law what would be her chances of having a healthy child