Circulation KIDNEYS ureters bladder Glomerulus (plasma filtration)‏ Tubule (reabsorption)‏ urethra URINARY-PROTEOME to the ureter 30% circulation 70% urogenital.

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circulation KIDNEYS ureters bladder Glomerulus (plasma filtration)‏ Tubule (reabsorption)‏ urethra URINARY-PROTEOME to the ureter 30% circulation 70% urogenital tract Figure 1 primitive urine = reabsorption NEPHRON final urine

Figure 2 Ureteropelvic junction (UPJ) obstruction Spontaneous resolution Relief surgery (pyeloplasty)‏ ? Intermediate obstruction Spontaneous resolution pyeloplasty birth1 to 2 years scintigraphies A B –1 – Membership 9 months spontaneous resolution surgery Clinical evolution 15 months Prediction based on urinary proteomics

Figure 3 LARGE DYNAMIC RANGE Ligand peptide library (millions of different ligands)‏ Flow-Through: Highly abundant proteins REDUCED DYNAMIC RANGE +

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