DEMI DABOR-ALLOH TGF-β Receptor II and Gastric Cancer
TGF-β Receptor II is a trans-membrane serine/threonine kinase
TGF β signalling regulates many cell processes including: Growth Inhibition Cell Migration Invasion Epithelial – Mesenchymal Transition Extracellular Matrix Remodelling Immune - suppression
Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and vasculogenesis
Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.
Some patients with gastric cancer have mutations that truncate the TGF-β RII protein
The TGF-β Paradox: it has Cytostatic effects vs. tumour favouring effects
Surgery is the primary treatment for gastric cancer Total Gastrectomy Endoscopic Mucosal Resection
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