A UTOIMMUNE D ISORDERS

I MMUNITY Normal process Promotes inflammation Fights off invasion Autoimmune response Major histocompatibility complex (MHC) AKA: Human leukocyte antigen (HLA) Self and non-self blurred

OSTEOARTHRITIS (NOT AUTOIMMUNE, BUT…) Wear and Tear on joints Affects mostly older adults; men & women Joint pain, stiffness Relieved by pain relievers and low- impact exercise

R HEUMATOID A RTHRITIS Autoimmune disorder Causes inflamed tissue that destroys cartilage Affects young and middle-age adults; more females than males May be very painful

A NKYLOSING S PONDYLITIS Another type of arthritis Affects the joints of the spine Likely genetic Symptoms / treatment

F IBROMYALGIA “Waste basket diagnosis” Complex, chronic pain disorder

F IBROMYALGIA C ONTINUED Diagnosis include Detailed history Pain in at least 11 of 18 designated tender points. Other diseases need to be ruled out first Symptoms include: Widespread pain, fatigue, sleep disorders, fibro “fog”, headaches, anxiety, and/or depression

C HRONIC F ATIGUE S YNDROME (CFS) Another “Waste basket diagnosis” AKA: Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease Diagnosis must meet 3 core symptoms: Impaired ability to engage in pre-illness levels for at least 6 months, with profound fatigue. Worsened symptoms after any type of exertion. Fatigue that persists even with sleep. (IOM, 2015)

S YSTEMIC L UPUS E RYTHEMATOSUS (SLE) Immune system produces antibodies causing inflammation and tissue damage. One main characteristic: butterfly facial rash Other symptoms May affect any organ in the body.

C ELIAC D ISEASE Controversial disorder Gluten ingestion leads to small intestine damage Symptoms Treatment Related conditions

A UTOIMMUNE DISORDERS Treatment Cognitive Behavior Therapy (CBT) Graded Exercise Therapy (GET) The importance of the biopsychosocial model Biopyschosocial Model GeneticsSocialPsychologyEnvironment