Team Members: Jon Klein Nguyen Vu Kyle Menges Christine Lowry Chris Stein Priya Narasimhan Julie Coggshall

Purpose Project Objectives Team Roles and Responsibilities Customer Needs and Specifications Expectations System Concept: Mechanical and Electrical Blood Sub-System Elements: Air Removal, Blood Extraction Dynamic Sub-System Elements: Compliance Chambers Static Sub-System Elements: Materials, Automated Resistance Electrical Elements: Flow, Pressure, and Temperature Sensors, DAQ Conclusions Pg.1

Design and build a test loop to help in LVAD development by characterizing the pressures and flows associated with the device as well as its impact on blood. Pg.2

1.Generate pressure and flow curves for static system (automatically adjusted) 2. Extracting fluids while running to determine damage to blood 3. Process data to generate pressure and flow curve for dynamic system (scaled model of the physiological circulatory system working with a PVS) Pg.2

Jon Klein Project Manager Kyle Menges Technical Lead Priya Narasimhan Electrical Engineer Julie Coggshall Industrial and Systems Engineer Christine Lowry Design Engineer (ME) Chris Stein Design Engineer (ME) Nguyen Vu Technical Lead Pg.2

Pg.26

Pg.3-4

To review the following material in order to gain input based off of attendees’ experience.

Pg.5

Pg.7

Pg.6

Subsystem Rank 123 TubingTygonABSMetal ResevoirBagsGravity DrivenOpen Top Valves3 Way Stainless3 Way PlasticNo Valves ComplianceTanksElastic MaterialMembrane Tanks ResistancePressure CuffServo Controlled ClampClamp Blood ExtractionThree Way ValvePressure Sensor TubingDouble Check Valve Pressure SensorsIntrusive DifferentialIntrusive DisposableSuspended Transducer Flow SensorsUltrasonic Clamp-onIntrusive PTFE Temperature SensorsThermocoupleInfrared Temperature ControlHeat ExchangerHot PlateWater Bath Leak TestTracer-FluidPressure Decay/FlowBubble Test See Concept Selection Matrix for full analysis

N RISK Air bubbles cannot be removed from system9 System or components leak causing error in measurement and/or contamination 4 Pg.23

N RISK Method for keeping constant temperature (98 deg F) not within budget 4 Human body temperature is not maintained 4 Blood is damaged due to the heating process 6 Viscosity variation does not simulate human blood properties 2 Pg.18-19

Venous Vein Less elastic Thin wall Does not help drive flow Arterial Resistance Figure 1: Artery and Vein Graphic Artery More elastic Thick wall Helps drive flow P Pressure Gage Air Valve Figure 2: Compliance Tank Drawing Air Resistance Cuff N RISK Resistance Automation 6 Specified compliance values not achieved 4 Flow restriction does not function properly 3 System or components leak causing error in measurement and/or contamination 4 Pg.12-16

Resistance Calculations V air =Volume of air in tank A tank = Cross sectional area of tank V tank =Volume of tank P fluid =absolute pressure of fluid Tank size Calculations = density of fluid g=Acceleration due to gravity C= Compliance P air =absolute pressure of air Source: University of Virginia Article, Design Initial testing of a mock human circulatory loop to test LVAD performance Source: Berne R. etal Physiology 4 th edition Mosby, St Louis 1998 N Pg.13

PVC Valves Stainless Steel Valves N RISK System or components leak causing error in measurement and/or contamination 4 Valves, sensors, tubing degrade over time2 Not all components are biocompatible 4 Valves, sensors, connectors damage blood 9 Pg.21

N RISK Desired sensor accuracy not within budget 6 Pressure and flow measurements are inaccurate 2 Instrumentation and DAQ not communicating properly, DAQ does not collect or output data properly 6 Pg.8

N RISK Desired sensor accuracy not within budget 6 Pressure and flow measurements are inaccurate 2 Instrumentation and DAQ not communicating properly, DAQ does not collect or output data properly 6 Pg.9

N RISK Desired sensor accuracy not within budget 6 Pressure and flow measurements are inaccurate 2 Instrumentation and DAQ not communicating properly, DAQ does not collect or output data properly 6 Pg.10

N RISK Dedicated DAQ system not within budget 6 Instrumentation and DAQ not communicating properly, DAQ does not collect or output data properly 6 Pg.11

N