QUANTOS – Quantum Leap in the Lab Amrit Duhela UK Powder Dosing Specialist

Internal usage only 1 QUANTOS – Quantum Leap in the Lab As of today… …the spatula is obsolete  Replacing the spatula means: - Automated dosing of small quantities of free-flowing substances  QUANTOS doses to target weight without exceeding set tolerances - Fast, safe and economical

Internal usage only 2 QUANTOS – Stand alone unit - Closed System  Draft shield is completely closed while dosing - Ideal for using in safety cabinet, glove box, isolator - Minimize sample spillage - Better repeatability » Smaller minimum weight » 1 mg to 1%, 10mg to 0.1% » Save the usage of precious/rare materials - Can dose directly into volumetric flask No more weighing paper or weighing boat necessary - Easy to use with touch screen panel and easy guidance

Internal usage only 3 QUANTOS – Sampler for Additional Automation  QS30 Sampler for repetitive operator- free dosings - 30 Positions - Vials with max. Ø 24mm - Vials with max. height 110mm - 6 carriages each with 5 numbered positions  Takes a few minutes to prepare all 30 vials and load the sampler…  …press START…  ….all vials are filled accurately without operator intervention

Internal usage only 4 QUANTOS – Video

Internal usage only 5 QUANTOS – Liquid Module QB-L  Standard Prep - Dispense directly into HPLC vial - Gravemetric is more accuracte than volumetric - Make required standard no wastage  Liquid Dispense - Gravemetric is more accuracte than volumetric - Safety aspect

Internal usage only 6 QUANTOS pays for itself Speed 1 mg to 250 mg in 15 to 60 sec Faster process = time to market Safety Hazardous substances remain sealed Protects personnel and substances Savings 8 to 50% less substance quantities to achieve the same result. Lower substances quantities

Internal usage only 7 QUANTOS Target Applications Filling Abbott Catalent Schering- Plough Bachem Portioning Capsule Filling Speed Safety Speed Application Stability Testing API Standards Animal Testing FiH Clinical Trials Task Driver Typical Existing Customers Fine Chem. Producers Pharma Testing Groups Screening Alcotek Amgen Astra- Zeneca Avantium Parallel Formulation Miniblock Reactor Safety Speed Accuracy Speed API Formulation Catalyst Screening Pharma Screening Biotech Screening QA/QC Novartis Merck Baxter Wyeth Standards Samples Method Validation Safety Accuracy Speed HPLC Analysis GC Analysis Titration TA Fine Chem. Producers Pharma Testing Groups Compound Management Novartis Pfizer Servier Sanofi- Aventis Portioning Speed Library Automation Pharma Libraries

Internal usage only 8 Sample Preparation for Analytical Methods Auto Powder Dosing (typical mg) API Testing with HPLC Step 1Step 2 Transfer to 2ml HPLC Vial (typical 1% accuracy) Step 3 Step 4 Solvent Addition and Dissolve (typical 1:1000) 2ml vial QUANTOS doses to target weight without exceeding tolerances fast, safe and economical

Internal usage only 9 Bottling: Repetitive filling of vials Auto Powder Dosing (typical mg) Step 1Step 2Step 3 Load Sampler with up to 30 vials vials/substance Step 4 Labelling & storage QUANTOS doses to target weight without exceeding tolerances fast, safe and economical

Internal usage only 10 Bottling: capsule filling for pre-clinical trials Auto Powder Dosing (typical mg) With respect to individual target dose Step 1Step 2Step 3 Load Sampler with up to 30 capsules Size 13, 12, 11, 10, 000, 00, capsules/day Step 4 Pre-clinical trials QUANTOS doses to target weight without exceeding tolerances fast, safe and economical

Internal usage only 11 Quantos – Coming soon ……. Upgrade your standard XP analytical balance To do a lot more……. Target customer’s are current installed base Discuss customers applications

Internal usage only 12 The dose head

Internal usage only 13 Dose head portfolio

Internal usage only 14 SafePos feature 14  Reduces spillage  Reduces electrostatic effects  Improves positioning  Available with the Q2 dosing units

Internal usage only 15 QUANTOS – Video

Internal usage only 16 LabX direct QuantosConnect: sequences 16

Internal usage only 17 LabX direct QuantosConnect 17 New features: Connects through RS232 or TCP/IP to Quantos Runs as Windows Service: receive all data Sequence programming: import, edit and run your dosing jobs with Quantos using a sample changer.

Internal usage only 18 Quantos Connected to your system 18  3 software products for this: Instem – Provantis – Dispense PDS – ToxData – Drug Base Xybion – Pristma – Pharmacy

Internal usage only 19 Contact Details :