Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov ) M F Fears TR, Tucker MA. J Natl Cancer Inst.

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Presentation transcript:

Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program ( ) M F Fears TR, Tucker MA. J Natl Cancer Inst. 2005, 97: Frances Noonan,

Photobiology of melanoma Wavelengths responsible-UVA, UVB or both ?Wavelengths responsible-UVA, UVB or both ? Critical UV-induced molecular alterations to melanocytes ?Critical UV-induced molecular alterations to melanocytes ? Pigment- protective or promotional ?Pigment- protective or promotional ? Role of the immune system – UV effects on immunity?Role of the immune system – UV effects on immunity? Frances Noonan, EOH,SPHHS

Melanoma induced by UV irradiation of HGF/SF transgenic mice Noonan et al., Nature, 2001; Recio et al, Cancer Res, 2002; in prep Frances Noonan, EOH,SPHHS

Functional Mc1r is necessary for UV-induced melanoma YELLOW BLACK Frances Noonan, EOH,SPHHS

Neonatal host UV irradiation promotes melanoma outgrowth Heather Poetschke-Klug et al Frances Noonan, EOH,SPHHS

Acknowledgements Photobiology lab, GWUMCPhotobiology lab, GWUMC –Ed De Fabo –J. Bahn; research assistants and students –Agnieszka Wolnicka-Glubisz; Stephanie Constant; Jesse Damsker Glenn Merlino, NCI/NIHGlenn Merlino, NCI/NIH Miriam Anver, SAIC, FCRFMiriam Anver, SAIC, FCRF Funding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMCFunding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMC Frances Noonan, EOH,SPHHS