John J. Lanza, MD, PhD, MPH, FAAP Florida Department of Health A Public and Clinical Health Perspective

American Ebola Patients

Dr. Brantley Arriving at Emory ( Early August, 2014)

Dr. Brantley Leaving Emory (Aug. 21, 2014)

Objectives To review the epidemiology of Ebola To understand the transmission risk from the Ebola virus To review the infection prevention and control recommendations for Ebola patients To understand the therapeutic options for Ebola patients

Virus Classification Group: Group V (-)ssRNA.(-)ssRNA Order: MononegaviralesMononegavirales Family: FiloviridaeFiloviridae Genus: Ebolavirus Ebola’s natural reservoir is unknown. Non human primates have been the source of human infections but are not thought to be the reservoirs.

History Named after the Ebola River in the Democratic Republic of the Congo (formerly Zaire), near the first epidemics.Ebola RiverDemocratic Republic of the Congo Two species were identified in 1976: –Zaire Ebolavirus (ZEBOV) and –Sudan Ebolavirus (SEBOV) Case fatality rates of up to 83% and 54%, respectively. A third species, Reston Ebolavirus (REBOV), was discovered in November 1989 in a group of monkeys (Macaca fascicularis) imported from the Philippines. Ivory Coast Ebolavirus – Only one case in an unlucky scientist.

Current Outbreak Problems Nothing unusual about the virus Dysfunctional public health and medical system Lack of local and international government actions Population does not understand the disease and its dangers & what to do

W E S T A F R I C A Ebola Outbreak

Ebola Cases and Deaths (West Africa) (Updated: Sept. 29, 2014) Suspected and Confirmed Case Count: 6574 Suspected Case Deaths: 3091 Laboratory Confirmed Cases: 3626