Psychosis in Dementia Conclusions Psychosis in dementia is distressful and disturbing to patients and  Is similar across the spectrum of the dementia  Is common  Can be identified  Is persistent

Psychosis in Dementia Methods Janssen has 2 databases of 1603 patients:  Data contains information from 2 studies:  Mild to moderate AD, community-dwelling  Severe AD, nursing home residents  The placebo data from these trials describes a natural history of psychosis in AD (n=285); (n=162) What was done with the data:  Experts correlated scale-items and item-scores with their clinical experience to identify characteristics of AD patients with psychosis  Delusions/hallucinations subscales: NPI of 4 or greater or BEHAVE- AD of 2 or greater

Mild to Moderate AD, community dwelling (n=285) Severe AD, nursing home (n=162) Women = 62% Mean age = 77 years Mean MMSE = % had AD Women = 67% Mean age = 83 years Mean MMSE = 7 Psychosis in Dementia Demographics 84% had AD

Psychosis in Dementia Community Based & Nursing Home Residents with Alzheimer’s Disease ~7 in 10 nursing home residents had psychosis during the study ~2 in 10 community dwelling AD patients had psychosis during the study

Psychosis in Dementia Results Community Dwelling (n=285) Nursing Home (n=162)  12% had psychosis at baseline  2/3 had symptoms that persisted for at least 1 month  1/3 had symptoms that persisted for at least 5 months  12% developed a psychosis  64% had psychosis at baseline  >2/3 had symptoms that persisted for at least 2 weeks  1/2 had symptoms that persisted for at least 4 weeks  17% developed a psychosis

Psychosis in Dementia Conclusions Psychosis in dementia is distressful and disturbing to patients and  Is similar across the spectrum of the dementia  Is common  Can be identified  Is persistent