ACS Presentation 4-9-13 F.H. Stillinger View 1. ACS Presentation 4-9-13 F.H. Stillinger View 2.

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Asymmetric Synthesis Introduction.

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ACS Presentation F.H. Stillinger View 1

ACS Presentation F.H. Stillinger View 2

SOME RELEVANT PUBLICATIONS: Homogeneous Solution Lattice Model [E = experiment, T = theory] 1. F.C. Frank, "On Spontaneous Asymmetric Synthesis", Biochim. Biophys. Acta, 11, (1953). [T] 2. K. Soai, T. Shibata, H. Morioka, and K. Choji, "Asymmetric Autocatalysis and Amplification of Enantiomeric Excess of a Chiral Molecule", Nature 378, (1995). [E] 3. D. Blackmond, C.R. McMillan, S. Ramdeehul, A. Schorm, and J.M. Brown, "Origin of Asymmetric Amplification in Autocatalytic Alkylzinc Additions", J. Am. Chem. Soc. 123, (2001). [E] 4. H.W. Hatch, F.H. Stillinger, and P.G. Debenedetti, "Chiral Symmetry Breaking in a Microscopic Model with Asymmetric Autocatalysis and Inhibition", J. Chem. Phys. 133, (2010). [T] 5. F. Ricci, F.H. Stillinger, and P.G. Debenedetti, "Creation and Persistence of Chiral Asymmetry in a Microscopically Reversible Molecular Model", J. Phys. Chem. B 117, (2013). [T] ACS Presentation F.H. Stillinger View 3

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βE rac = 5, p attr = 0.4, K = 1, ee C 0 = 0.055, N total = , N eq = 10000, N L 0 = With agglomeration ACS Presentation F.H. Stillinger View 20

βE rac = 5, p attr = varying, K = 1, ee C 0 = 0.055, N total = , N eq = 10000, N L 0 = With agglomeration ACS Presentation F.H. Stillinger View 21

βE rac = 5, p attr = varying, K = 1, ee C 0 = 0.055, N total = , N eq = 10000, N L 0 = With agglomeration ACS Presentation F.H. Stillinger View 22