(A) (B) Supplementary Figure S1. FSC-A Live/Dead CD3 NK1.1 CD4 CD8 4-1BB PD-1 4-1BB PD-1 CD4+CD8+CD3+Live cells (A) Isotype-treated FSC-A Live/Dead CD3.

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(A) (B) Supplementary Figure S1

FSC-A Live/Dead CD3 NK1.1 CD4 CD8 4-1BB PD-1 4-1BB PD-1 CD4+CD8+CD3+Live cells (A) Isotype-treated FSC-A Live/Dead CD3 NK1.1 CD4 CD8 4-1BB PD-1 4-1BB PD-1 CD4+CD8+CD3+Live cells (B) Anti-4-1BB-treated Supplementary Figure S2

Supplementary Figure S3

(A)(B)(C) Supplementary Figure S4

Supplementary Figure S5

Supplementary Tables Table S1A Incidence and Severity of Microscopic Findings in the Liver Group 1 (PBS), Group 2-4 (0.1, 1, or 5 mg/kg 4-1BB agonist mAb, respectively), Group 5 (20 mg/kg PD- antagonist mAb), Group 6-8 (20 mg/kg PD-1 antagonist mAb plus 0.1, 1, or 5 mg/kg 4-1BB agonist mAb, respectively) mice were euthanized for necropsy and histological analysis 10 days after a single subcutaneous administration. Microscopic findingGroup 1Group 2Group 3Group 4Group 5Group 6Group 7Group 8 Mixed Cell Infiltration3/54/55/5 4/55/5 Minimal Mild Moderate Marked Single Cell Necrosis0/5 5/5 0/5 5/5 Minimal Mild Supplementary Table S1A

Table S1B Incidence and Severity of Microscopic Findings in the Spleen See Table 1a for group assignments. * Extramedulary hematopoiesis Microscopic FindingsGroup 1Group 2Group 3Group 4Group 5Group 6Group 7Group 8 Lymphoid Hyperplasia1/53/54/5 5/5 Minimal Mild Moderate ---1 Increased EMH * 2/5 1/50/55/5 Minimal Mild Supplementary Table S1B