Credo Xtreme ® Shipper vs. Active Container By: Manuel G. Sardinas, ME, CSCP Clinical Supply Operations Logistics Manager Americas Bristol-Myers Squibb

Opportunities: o Reduction of carbon footprint in Clinical Supply chain o Reduce operational costs Challenges: o Maintain product integrity (Conditions 2˚- 8˚C) o Evolving and dynamic Clinical Supply chain o Active container lane limitation o Customs delays o Logistics delays  Active container securing Time (7 business days)  Active container availability (peak season challenges) Bristol-Myers Squibb Cold Chain Opportunities

Credo Xtreme ® Model Credo Xtreme ® shipment starts Shipment to destination Country Integrated Business Partner receives drug material for clinical site distribution Credo Xtreme ® is processed to be transported back to origin Credo Xtreme ® is transported back to HUB Warehouse Credo Xtreme ® is received in HUB Warehouse and it is maintained to be reused

Advantages: Reusable technology Lower projected cost of ownership Efficient use of the payload (up to 98%) Active container securing time delay avoided Flexible to any lane Disadvantages: Reverse logistics Manual operation Credo Xtreme® Model Full Pallet Xtreme®Active Container Capacity890 L2300 L Payload Dimensions 41.21” x 33.21” x 39.70”52.7" x 51.9" x 51.7" Exterior Dimensions 48.0” x 40.0” x 52.0”78.7" x 60.2" x 63.8" Thermal Performance 120 hours100 hours without being connected Tare Weight548 lb1400 lb Use of Payload % %

Factors: Total Cost of Ownership of current Technology Investment and Depreciation of Credo Xtreme ® Units Include Forwards and Reverse Logistics o Importation Fees o Customs Charges Results: Savings in year 0 Savings in 5-Year Term Financial Model Projection

Credo Xtreme ® qualification Vendor collaboration (DHL, MTS, Logistics Partners in each country, Customs Agents) Guide Development and Training Reverse Logistics Process Implementation: Latin America, EU Credo Xtreme ® Testing Communication to Network Country Warehouses Obtain Inventory Launch Post-launch Monitoring and Tracking Project Deployment

Vendor Collaboration – Reverse Logistics Process Development U.S. Customs Subject-Matter Experts Local Import/Export Agents (Destination Country) Local Integrated Partner (Country Warehouse) Transportation Integrated Partners HUB Process Monitor HUB Warehouse Service Integrated Partner

Shipper performance o No temperature excursion using Credo Xtreme ® Carbon emissions reduction o Average reduction per shipment: 41% Realized savings o Average cost reduction per shipment: 65% Lead Time eliminated Results

Commitment to “green” technology Commitment to reducing operational cost Costumer-focus service of integrated partners Detailed and accurate financial models Available options while implementing project Frequent communication Process development Success Factors

Q&A Manuel G. Sardinas, ME, CSCP