General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc Hydrolysis of Amides Chapter 18 Amines and Amides

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.2 Hydrolysis of Amides Amides undergo acid hydrolysis base hydrolysis to form to form carboxylic acid salt of carboxylic acid and an ammonium salt and an amine or ammonia

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.3 Acid hydrolysis of an amide  involves an acid and water  produces the carboxylic acid and the ammonium salt Acid Hydrolysis of Amides

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.4 Base hydrolysis of an amide  involves a base and water  produces the salt of the carboxylic acid and the amine Base Hydrolysis of Amides

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.5 Write the equation for the hydrolysis of N-ethylpropanamide with NaOH. Learning Check

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc.6 Write the equation for the hydrolysis of N-ethylpropanamide with NaOH. Solution