Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation by Roberto.

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Presentation transcript:

Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation by Roberto Crocchiolo, Elisabetta Zino, Luca Vago, Rosi Oneto, Barbara Bruno, Simona Pollichieni, Nicoletta Sacchi, Maria Pia Sormani, Jessica Marcon, Teresa Lamparelli, Renato Fanin, Lucia Garbarino, Valeria Miotti, Giuseppe Bandini, Alberto Bosi, Fabio Ciceri, Andrea Bacigalupo, Katharina Fleischhauer, and Blood Volume 114(7): August 13, 2009 ©2009 by American Society of Hematology

An algorithm for nonpermissive HLA-DPB1 disparities according to TCE3 or TCE4. Roberto Crocchiolo et al. Blood 2009;114: ©2009 by American Society of Hematology

Impact of allelic or allele-group HLA-DPB1 disparities on OS after unrelated HSCT. Shown are Kaplan-Meier estimates of survival. Roberto Crocchiolo et al. Blood 2009;114: ©2009 by American Society of Hematology

Predictive value of TCE3 and TCE4 for OS after unrelated HSCT, stratified according to matching status at other HLA loci. Roberto Crocchiolo et al. Blood 2009;114: ©2009 by American Society of Hematology

Association of nonpermissive HLA-DPB1 disparities according to TCE4 with increased mortality is seen both in early and in advanced disease. Roberto Crocchiolo et al. Blood 2009;114: ©2009 by American Society of Hematology

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