Occupational Neurotoxicology H.R.Sarreshtahdar, MD Occupational Medicine Specialist.

Slides:



Advertisements
Similar presentations
MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons.
Advertisements

TOXIC INJURY OF THE CNS Bennet I. Omalu, MD 1.
Chris Martin, MD, MSc, FRCPC Director, Institute of Occupational and Environmental Health Occupational and Environmental Medical Association.
Principles of Neurological Diagnosis
Chapter 36 Disorders of Neuromuscular Function
Vivian & slides from ESA mentoring 2013
Acute Peripheral Weakness Peter Shearer, MD Assistant Residency Director Mt. Sinai School of Medicine.
NEUROPATHOPHYSIOLOGY III Trauma, Stroke and Toxins Nancy Long Sieber, Ph.D. September 27, 2010.
Rob Rubenstein MD Neurologist - The Doctors Clinic Topic – EMG/NCV Testing.
Disorders of peripheral nerves. Symptoms and signs of disorders of nerves Caused by changes in axons –Increased conduction time –Increased temporal dispersion.
ALCOHOL AND THE NERVOUS SYSTEM DR M KAKAZA. COMMON COMPLICATIONS Nutritional deficiency Diseases partly nutritional in origin Direct effects of alcohol.
NERVOUS SYSTEM TOXICOLOGY. OUTLINE Nervous system development Nervous system anatomy and physiology Manifestations of neurotoxicity –Neuronopathies –Axonopathies.
Pathophysiologic Results of Neurologic Oncologic Disorders Manifestations depend upon the tissues infiltrated and compressed by the neoplasm Pathophysiologic.
Ataxia and Gait Disturbances Presented by A. Hillier, D.O. EM Resident St. John West Shore Hospital.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 36 Disorders of Neuromuscular Function.
Neuromuscular Disorders Brenda P. Johnson, PhD, RN.
Nervous System Human Body Systems Project Caroline Crinion.
1 Weakness & Sensory Deficit Describe unique findings in Myopathy, NMJ disorder, neuropathy, plexopathy, radiculopathy Myelopathy, motor neuron disease.
Neurological Assessment PN 2 Assessment Summer 2007 Liz Mathewson.
Degenerative Diseases of Brain. Degenerative Diseases Spontaneous, progressive degeneration of neurons Sporadic, Familial Overlapping features.
Neuropathology Review Questions 11/2/2012. Match the metal with the toxicity or description Arsenic Lead Mercury Manganese 1.Mees’ transverse white lines.
Dayna Ryan, PT, DPT Winter 2012
INHALANT ABUSE And What To Do About It.
Neurotoxicity in Occupational Health
SPINAL NERVE ROOT COMPRESSION AND PERIPHERAL NERVE DISORDERS Group A – AHD Dr. Gary Greenberg.
Abnormal gait دکترامیر هوشنگ واحدی متخصص طب فیزیکی و توانبخشی قسمت 2.
Multiple Sclerosis A chronic, progressive central nervous system disease with a disseminating demyelination of the nerve fibers of the brain and spinal.
Demyelinating Disease August 27, Pathologic Criteria Destruction of myelin Sparing of other elements of the nervous tissue Infiltration of inflammatory.
Diarrhea and Neuro Sx Seizures (shigella) Blurred vision, diplopia, dysarthria, dysphagia, descending paralysis (Clostridium botulinum Headache, dizziness.
Why studying neurosciences? Neurological symptoms account for high % of consultation in general practice. Accounts for 20% of acute admissions to hospitals,
Alex Wiemann. Function of Nervous System Coordinates actions and transmits signals between parts of a body.
Out-patient Management in Neurology
Disorders of Motor Development in Terms of Neuroscience Pediatric Course - Pathophysiology.
SOLVENTS. P HYSICAL AND CHEMICAL PROPERTIES : Solubility Flammability Volatility Chemical structure.
Group A – AHD Dr. Gary Greenberg
Nervous System Diseases & Disorders Notes. Head Trauma #1 cause of trauma deaths in US Many possible mechanisms of injury: Falls Motor vehicle crashes.
Neurologic Complications of HIV Infection
 Episodes of abnormal sudden, excessive, uncontrolled electrical discharge of neurons within the brain  May result in alteration in consciousness,
DISORDERS OF THE NERVOUS SYSTEM Dr. Alireza Safaeian MD Occupational Medicine Specialist.
Pathology of The Nervous System Dr. Mohamed seyam phd.pt.
Douglas Todey. Functions It has three main basic functions Sensory neurons receive information from sensory receptors Interneurons transfer and interpret.
Neurological Exam: Still Important After All These Years Eric Kraus, MD Neurology.
Introduction to Neurotoxicology. Functions of the Nervous System Detect sensory inputs Communication Integration and processing of responses Neuroendocrine.
Peripheral Neuropathy Clinical Management Course February 12, 2007
1 Neurotoxic Effects from Exposure to Organic Solvents.
The organization of the nervous system. Structure of the human cerebral cortex.
The Child with Motor Weakness Neurology Module Pediatrics II.
Localising the lesion – where in the nervous system?
Presented by: Vidyaningtyas BA, MD Yanuarita T, MD Widagdo S, MD.
Peripheral nerve disease Peripheral nerve disease.
The Neuromuscular Manifestations of Amyloidosis
Do Now 2/9/15 1.Describe possible causes for forgetting a memory. 2.Compare and contrast semantic and episodic memories.
Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 19 Disorders of Motor Function.
陳京瑜.  Inflammatory  Infectious  Hereditary  Acquired metabolic and toxic  Traumatic  Tumor.
Peripheral nerve disorders: A practical overview Praveen Dayalu, MD Clinical Associate Professor Department of Neurology University of Michigan.
STARRS. STARRS Characteristics One way to describe muscle function and movement Rating Scale from 0-4 with 0 indicating normal function 1 mild impairment.
The wrist and the hand. Wrist anatomy Radius forms wrist joint with scaphoid, lunate & triquetrum.
Nervous System Disorders
Dr Massud Wasel MD DO ND BSc(Hons) P.G.C.A.P
Disorders of Movement, Sensation, and Mental Function Chapter 21
Nervous System Disorders and Homeostatic Imbalances
By: Dr A.Mortazavi.
Neurotoxicology A. H. Mehrparvar, MD Occupational Medicine department
Substance-Related AND Addictive Disorders/Drug Abuse
Long Term Effects of Concussions
The Motor System Chapter 8.
Neurological complications of diabetes mellitus, anemia, alcoholism, collagenous disorders DM,
Occupational Neurologic Disease
PEREHHRAL NERVOUS SYSTEM
LHON/LHON plus Andrea Gropman, M.D., FAAP, FACMG, FANA
Presentation transcript:

Occupational Neurotoxicology H.R.Sarreshtahdar, MD Occupational Medicine Specialist

General Principles  Dose-Toxicity relationship  Nonfocal or symmetrical sign  Temporal relationship  Multiple neurologic syn. Some recovery is possible after removal of the insulting agent Few toxins present with pathognomonic neurologic syndrome.

APPROACH TO PATIENTS 1) Sufficient intense or prolonged exposure to the toxin. 2) An appropriate neurologic syndrome based on knowledge about the putative toxin. 3) Evalution of symptoms and signs over a compatible temporal course. 4) Exclusion of other neurologic disorders that may account for a similar syndrome.

Central Nervous System(CNS)  Diffuse toxic encephalopathy Acute Chronic  Selective toxic encephalopathy Cell bodies Ion channels Neurotransmitter system

Pripheral Nervous System(PNS)  Polyneuropathy  Myeloneuropathy

Neurotoxins

Specific Neurotoxins  Metals Lead Arsenic Manganese Mercury  Pesticides Organophosphates  Solvents Carbon disulfide n-Hexane Methanol Trichloroethylene  Plastics Acrylamide  Gases Nitrous oxide Ethylene oxide Methyl bromide

Lead  Massive intoxication :  Lead encephalopathy: lead blood levels of µ g/dl convulsions, cerebral edema, coma, transtentorial herniation.  Chronic low-level exposure : impaired intellectual development in children.

Lead  Classic: bilateral wrist-drop and foot-drop.  The best known clinical syndrome is a predominantly motor neuropathy with little if any sensory symptoms.  Toxicity also may manifest as a generalized proximal & distal weakness and loss of DTR.  lead level > 40 µ g/dl: Asymptomatic & NCV abnormalities:

Mercury  Organic mercury :CNS disturbances (tremor, cerebellar ataxia, hearing Loss, visual field constriction, hyperreflexia and Babinski sign)  Inorganic mercury: PNS,Neuropathy = Guillain-Barre syndrome

Arsenic  The most common manifestation of neurotoxicity : Peripheral neuropathy. Symmetrical sensorimotor polyneuropathy  Single massive dose: acute polyneuropathy( 1-3 weeks) = Guillain-Barre syn.

Manganese  extrapyramidal disorder (idiopathic Parkinson)  Compared to idiopathic Parkinson disease, the extrapyramidal symptoms of manganism are less responsive to dopaminergic therapy.  neurologic deficits often continue to progress for many years after cessation of exposure

Carbon Monoxide  %: headache and mild confusion.  %: stupor  1% more than 30 minutes can be fatal.  More prolonged or severe hypoxia is accompanied by a varying combination of tremor, chorea, spasticity, dystonia, rigidity, and bradykinesia. encephalopathy, parkinsonism are relatively common.

Nitrous Oxide  Myeloneuropathy =Vitamin B 12 deficiency.  Paresthesias in the hands and feet.  Gait ataxia, sensory loss, Romberg sign.  DTR :diminished or lost (peripheral neuropathy)  Serum vitamin B 12 and Schilling test are often normal.  serum homocysteine level may be elevated.

Hexacarbons (n-Hexane and Methyl n-Butyl Ketone)  acute encephalopathy euphoria, hallucination, and confusion.  The most well-known syndrome:glue- sniffer'sneuropathy distal symmetric sensorimotor polyneuropathy Early symptoms are paresthesias and sensory loss. Weakness involves distal muscles initially Proximal musculatures are affected in more severe cases.

SyndromeNeuroanatomySymptoms and SignsExamples Acute encephalopathy Diffuse; cerebral hemispheres headache, irritability, disorientation, convulsions, amnesia, psychosis, lethargy, stupor and coma Acute exposure to many toxins at sufficient doses Chronic encephalopathy Diffuse; cerebral hemispheres Cognitive and psychiatric dis- turbances Chronic or low-dose exposure to many toxins Parkinsonism Basal ganglia & other extra- pyramidal motor pathways Tremor, rigidity, bradykinesia, gait instability Mn, CO, Methanol Motor neuron disease Spinal cord motor neurons Muscle atrophy, weaknessLead, manganese Myeloneuropathy (myelopathy & polyneuropathy) Spinal cord & peripheral nerves Paresthesias, sensory loss, hyperreflexia, Babinski sign, NO, organophosphates, n-hexane Polyneuropathy Peripheral sensory, motor & autonomic nerve fibers Paresthesias, numbness, weakness, loss of DTR, autonomic failure Many toxins at sufficient doses

Focal nerve injuries  Radial nerve  Median nerve - carpal tunnel syn. - entrapment at elbow  Ulnar nerve -cubital nurve syn. -lesion at wrist  TOS