Completion of Skeletal Muscle and comparison to Smooth Muscle.

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Completion of Skeletal Muscle and comparison to Smooth Muscle

Outline Classification of Skeletal muscle  Slow twitch versus fast twitch  Oxidative versus glycolytic Skeletal Muscle Genetic Diseases Smooth Muscle  Types of smooth muscle cells  Smooth muscle contraction  Smooth muscle relaxation Smooth muscle compared to Skeletal Muscle

Classification of skeletal muscle Speed of contraction Resistance to Fatigue

Which type of muscle fibers are used for these two activities? Fast Twitch Slow Twitch Weight liftingPianist

Muscular Disease Muscular Dystrophy  Sex linked recessive  Dystrophin is mutated Myasthenia Gravis  Decreased number of acetylcholine receptors

TYPES OF SMOOTH MUSCLE CELLS

SMOOTH MUSCLE CONTRACTION NO SARCOMERES! Presence of Dense Bodies EXTRA CALCIUM STORAGE SITES

SMOOTH MUSCLE CONTRACTION at the MOLECULAR LEVEL No sacromeres No troponin

Look inside the smooth muscle cell

Smooth Muscle Relaxation

Comparisons: Smooth versus Skeletal Increase cytosolic calcium Calcium binds calmodulin Ca ++ Calmodulin activates MLCK MLCK activates myosin ATPase Shortening Increase of cytosolic calcium Calcium binds troponin Alteration in troponin moves tropomyosin Myosin binds actin Shortening

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