Ch 15 pictures. Is your clicker # on this list? 14, 23, 29, 36, 40, 53, 69, 74, 75, 92, 93, 99, 100. If so, let me know your name so I can give you credit.

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Presentation transcript:

Ch 15 pictures

Is your clicker # on this list? 14, 23, 29, 36, 40, 53, 69, 74, 75, 92, 93, 99, 100. If so, let me know your name so I can give you credit for attending class. Thanks! Dr. H

Today: Announcements

Historical Perspective 1860’s Mendel proposed that discrete factors segregated and independently assorted during gamete formation. Genetics Cytology 1875: Cytologists worked out the process of mitosis. 1890: Cytologists worked out the process of meiosis. 1900: Three botonists (Correns, deVries and von Seysenegg) independently rediscovered Mendel’s Principles 20 years after his death. Early 1902: Walter Sutton, Theodor Boveri and others hypothesized that genes are on chromosomes.

Thomas Hunt Morgan

Drosophila melanogaster

Morgan’s Symbols Wild Type Mutant

Morgan’s Symbols (homozygote recessive) (heterozygote) White Eyes = w Red Eyes = w+ w+ww+w ww

Morgan’s Symbols Curly Wings

Question 15.1

Sex-linkage in Drosophila

First Filial Generation of Fruit Flies Male Female w+ (X chromosome) w+ w w (X chromosome) Y chromosome w+ (X chromosome) w+ w w+ y F1 Phenotype All red Eyes Genotype Females= w+w Males= w+y Parentals

Second Filial Generation of Fruit Flies Male Female w+ (X chromosome) w+ w w+ (X chromosome) Y chromosome w (X chromosome) w+ w+ w+ y w y F2 3/4 red eyes 1/4 white eyes Only males had white eyes F1 generation

Y Chromosome in Humans

Recessive Disorders Red-green colorblindness Duchenne muscular Dystrophy (muscles break down and are eventually lost) Hemophilia (missing Blood clotting factor)

Question 15.2

Colorblind Inheritance in Females X cb Mother Father X cb Y

Alterations in Chromosomes

Fig Meiotic Nondisjunction

One copy of Chromosome #1 No chromosome #1 Fertilization One Chromosome #1 X Embryonic Lethal All others paired

Monosomy XO

Trisomy XXY

Trisomy Chromosome 21 (not in a sex chromosome)

Fig 15.14: Alterations in Chromosome Structure

Chromosome 5 deletion

Question 15.3

X inactivation and the tortoiseshell cat

Figure 15.9 Some chromosomal systems of sex determination

Question 15.4

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