Role of Rho-A in Glaucoma Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli.

Slides:

Advertisements

Similar presentations

Cell Signaling A. Types of Cell Signaling

Advertisements

Chapter 11 Cell Communication

ODEs part 3. Network model example Model considers positive feedback loops involving signalling pathways and/or gene regulation. Multiple interlinked.

Rho family GTPases Thuy Nguyen 3/6/2012

Year 1 : Animal Biology Revision

Cell Communication Chapter 11 Local regulators – in the vicinity a.Paracrine signaling – nearby Cells are acted on by signaling Cell (ie. Growth factor)

Cell to Cell Communication Ch.11 – Cell Communication Ch. 45 – Endocrine System Ch. 43 – Immune System Ch Nervous System.

How you See The eye & vision. How You See The eye collects light from objects and projects them on the light-sensitive portion of the eye, the retina.

How the eye sees Last time Anatomy of the eye Cells in the retina Rods and cones Visual receptors This time Visual receptors Visual transduction 1.

Cdc42 plays a key role in yeast cell polarization Chao Wang June 17, 2005.

Contraction and Excitation of Smooth Muscle

 The rods contain a light-sensitive pigment called rhodopsin.  Rhodopsin is made of 2 components: 1. Retinene/Retinal – the pigment portion made with.

RhoA, Cell Shape, and Orientation of Mitotic Spindle Are they related? Presented by: Tao Lin Jasneet Kaur.

Eye Structure and Function

Human Biology Sylvia S. Mader Michael Windelspecht

Smooth Muscle  Spindle-shaped cells 2-10  m across & ~100  m long  Have a thin endomysium  Organized into longitudinal and circular layers  Found.

Cell Structure and Function

Visual impairment.. 2 Objectives  Leading causes of visual impairment and blindness in the U.S.  How to assess a patients vision and ability to identify.

 Nucleus: contains most of the genes that control entire cell 1. Nuclear envelope: double membrane, encloses nucleus, regulates molecular traffic by.

The Cytoskeleton... Is a supportive meshwork of fine fibers inside eukaryotic cells Provides structural support Is involved in cell movement and movement.

EYE ANATOMY TUTORIAL LEARN THIS!. 1. Name the “third” eyelid (blue arrows). plica semilunaris.

Eye Structure and Seeing Light

Organization and Regulation of Body Systems

Sensory & Motor Systems. Some vocabulary: Sensation Action potentials that reach the brain via sensory neurons Perception The brain’s awareness of sensations.

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Anatomy of the Cell Cells differ (200 types), but share general structures Cells.

2) Vision The Special Senses 13 th edition Chapter 17 Pages th edition Chapter 17 Pages

Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere.

The Eyes and Vision. I. Anatomy of the Eye The eye consists of 3 layers or tunics Fibrous tunic- The eye consists of 3 layers or tunics Fibrous tunic-

Special Senses Lecture (Day 1:Eye anatomy & Vision)

Vision. Surface Anatomy of the Eye Eyebrows divert sweat from the eyes and contribute to facial expressions Eyelids (palpebrae) blink to protect the.

Cell Signaling basics.

INTRODUCTION Unit 8 - Cytoskeleton.

The EYE. Layers of the Eye Sclera Choroid layer Retina.

AP Biology Nervous Systems Part 5. Important concepts from previous units: Conformational shape change triggers a transduction pathway leading to response.

Cell Communication Chapter Cell Communication: An Overview  Cells communicate with one another through Direct channels of communication Specific.

U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Chapter 8: Contraction and Excitation of Smooth.

Tao Lin and Jasneet Kaur Lab Advisor: Dr. Edward Bonder Teaching Assistant: Susan Seipel.

Dr. Abdullah Al-Amri Ophthalmology Consultant

A view of the Cell. Discovery of cells Microscopes enabled biologists to see cells and develop the cell theory.

Medical School Histology Basics Eye

Pupil Lens Iris Cornea Retina Optic Nerve.

Tashkent Medical Academy

You Must Know  3 stages of cell communication Reception, transduction, & response  How G-protein-coupled receptors receive cell signals & start transduction.

Overview: The Cellular Internet Cell-to-cell communication is essential for multicellular organisms Biologists have discovered some universal mechanisms.

Chapter 11 Cell Communication. Cell communication signal cells communicate by direct contact or by secreting local regulators ex: growth factors, neurotransmitters.

Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.

Intercellular Junctions in Plants Plasmodesmata: channels in which plant cell walls are perforated with. Functions of Plasmodesmata include: –Allowing.

EYE The eye is an extension of the brain.

Bio 449Lecture 12 - Sensory Physiology IVSep. 22, 2010 Vision - the eye Gross structure and function Focusing mechanism Photoreceptors Structure Transduction.

Glaucoma Madhav Vempali Vempali Medical Ltd. Glaucoma The healthy eye Light rays enter the eye through the cornea, pupil and lens. These light rays are.

Perfusion Chamber with Porous Membrane for Cellular-Level Glaucoma Research Joey Labuz Holly Liske Laura Piechura Kellen Sheedy Donna Peters, PhD Department.

Cell Communication Chapter 11.

The human eye. What are the main parts of the human eye? Ciliary muscle Cornea Iris Lens Optic nerve Pupil Retina Sclera Vitreous humor Aqueous humor.

U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Contraction and Excitation of Smooth Muscle.

“Your Amazing Research Topic”

FIGURE Typical spatial organization of microtubules, stress fibers (one form of microfilaments), and intermediate filaments.

Factors that regulate the activity of GTP-binding proteins of the ras superfamily. In the active GTP-containing state (represented by a triangle) the protein.

Global prevalence of POAG

SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.

Smooth Muscle cells contain actin and myosin, but are quite different from skeletal and cardiac myocytes. 1) Where do we find smooth muscle under involuntary.

Glaucoma Introduction DR ANUPAMA .B.

Fig. 2 Increased ECM stiffness activates the Rho-mediated cell contractility pathway. Increased ECM stiffness activates the Rho-mediated cell contractility.

RhoA/Rho-Kinase: Pathophysiologic and Therapeutic Implications in Gastrointestinal Smooth Muscle Tone and Relaxation Satish Rattan, Benjamin R. Phillips,

A Hitchhiker's Guide to Mechanobiology

Spatiotemporal Regulation of RhoA during Cytokinesis

Energy transformation Extracellular components

Special Senses Visual Sense.

Presentation transcript:

Role of Rho-A in Glaucoma Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli

Outline Open angle Glaucoma RhoA pathway and hypothesis CATPA

Open Angle Glaucoma It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP)

Anatomy of the angle

Trabecular meshwork Shields textbook of glaucoma-2005 Cornea Retina

Cell cytoskeleton Green: actin Red: mitochondria Blue: nucleus

TM Cell Contractility Aqueous humor regulation is done by TM cell contractility and re-alignment of pores. There are two pathways that regulate TM contractility. Ca dependent pathways And the Ca independent pathway. Rho-a protein is involved in the Ca independent pathway.

General Function of Rho-A Involved in the maintenance of tight junctions. Tight junctions are found in epithelial cells and all cells where there is a separation or demarcation into different regions. If the Rho-A pathway does not function properly in the eye, it causes Glaucoma.

Ca independent pathway GDI GAP GEF GTP GDP P RhoA-GDP Plasma membrane Contraction Relaxation MLC pMLC M20 MYPT1 PP1C  Active MLCP M20 MYPT1 PP1C  Inactive MLCP RhoA-GDPRhoA-GTPRho kinase

CATPA

Point Mutations

References /rhoA/FRAMES/captxt.htmhttp://biology.kenyon.edu/BMB/Chime2/ PDB, CATH, SCOP http: //