Simulation of Interactions of Radiation with Biological Systems at the Cellular and DNA Level Based on Sponsored by Activity of
The concept of “dose” fails at cellular and DNA scales It is desirable to gain an understanding to the processes at all levels (macroscopic vs. microscopic+cybernetic) Quantitative knowledge and strict user requirements scientifically satisfying; may be used as feedback to experimentalists Potential later connection to other than radiation-induced effects at the cellular and DNA level Relevance for space: astronaut and airline pilot radiation hazards, biological experiments. Applications in radiotherapy, radiobiology,... Relevance
Solar flare electrons, protons, and heavy ions Jovian electrons Solar flare neutrons and -rays Solar X-rays Galactic and extra-galactic cosmic rays Induced emission (Neutrinos) Trapped particles Anomalous cosmic rays
Relevance for space: astronaut and aircrew radiation hazards
Programme description -based “sister” activity to the Geant4 Low-E e.m. Working Group. Follows rigorous software standards ESA-sponsored + INFN official activity Simulation of nano-scale effects of radiation at the DNA level Multiple approaches (RBE parameterisation, detailed biochemical processes, etc.) can be implemented with Geant4 Various scientific domains involved: medical, biology, genetics, software engineering, high and low energy physics, space physics