The Quest For The Cure of Neurological Disorders

Slides:



Advertisements
Similar presentations
Cognition enhancing or neuroprotective compounds for the treatment of cognitive disorders: why? when? which? Lockhart BP, Lestage PJ. January 2003.
Advertisements

Professor of Experimental Psychology Department of Psychology Veena Kumari.
Growth Factor (GF) Cascades and exercise and the regulation of cognition, mood and motor control: Are GFs a common mechanism? Carl W. Cotman Director,
Alzheimer’s Disease Edwin Onattu P. 3.
Etiopathogenesis of Alzheimer's disease
Anchored Periplasmic Expression (APEx) A Powerful Technology for Antibody Discovery and Combinatorial Protein Library Screening George Georgiou, Dept.
TBI & Degenerative Conditions. Traumatic Brain Injury (TBI)
OXIDATIVE STRESS. INDUCTION OF OXIDATIVE STRESS Glutathione conjugation MalnutritionMutation Phagocytic activation Tissue damageSmoking.
Healthy Mind, Healthy Sight.. u Dr. Guy Eakin, BrightFocus Foundation u Dr. Elia Duh, Johns Hopkins University u Dr. Seth Margolis, Johns Hopkins University.
Stem Cell Research Michael Sherman. Negative Attitude towards Cell Research Destruction of Embryo for Stem Cells Catholicism.
AGING AND TRAUMA Key Points Increased longevity results in increased neurological disorders ‘Normal’ age-related changes in brain structure Neurodegenerative.
Effects of testosterone and social interactions on adult neurogenesis in male rats. Vermont Genetics Network Annual Retreat, August Mark D. Spritzer.
NEUROLOGICAL DISORDERS. Dementia  A degenerative syndrome characterized by deficits in memory, language, and mood.  The most common form: Alzheimer’s.
The Myc Transcription Factor
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. Susan A. Farr, et al.
Different types of cloning
PEPTIMMUNE CONFIDENTIAL IMMUNOMODULATORY THERAPY FOR PARKINSON’S DISEASE Induction of an anti-inflammatory immune response toward toxic species of alpha-synuclein.
Clear organic causes, where primary symptom is a significant deficit in cognitive ability changes in the person’s personality and behavior (due to the.
STEM CELL RESEARCH. Pros or Cons KX7lfmv-KQCFVB95QodVDwNigstem cell research
Peptides from Scorpion Venom and Autoimmune diseases K. George Chandy, Department of Physiology and Biophysics, University of California Irvine.
Best Nutrition for a Fit Brain Majid Fotuhi, MD PhD Vantage House Columbia, MD October 16, 2014.
How Heat Can Affect the Development of Amyloid Plaques in Alzheimer’s Disease RESEARCH PROPOSAL BY ALEXANDER J. COLÓN.
Follow Up Questions Diabetes is caused by an increase in blood glucose. People with diabetes II also have a very high risk for developing Alzheimer’s disease.
Genetic Manipulation of Mouse ES Cells toward a Specific Neuronal Fate Anne Chiaramello, Ph.D Associate Professor George Washington University Medical.
MRI as a Potential Surrogate Marker in the ADCS MCI Trial
Peptides from Scorpion Venom and Autoimmune diseases K. George Chandy, Department of Physiology and Biophysics, University of California Irvine.
NEUROLOGICAL DISORDERS. Dementia  A degenerative syndrome characterized by deficits in memory, language, and mood.  The most common form: Alzheimer’s.
Neurological Disorders
Types of Cloning Reproductive Cloning – making copies of a whole animal/human – useful to propagate transgenic /genetically modified organisms Therapeutic.
Under the supervision of miklós jászberényi
Sortilin-related receptor and Alzheimer’s disease
Process of study selection F. Sofi, et al. BMJ 2008 Sep 11;337:a1344.
Measuring the Effect of Silencing the APP gene and Stimulating the CaMKII Pathway on Synaptic Plasticity in Alzheimer’s Disease Harshita Nangunuri.
ANTHONY SPRANGERS EPD 397 PROFESSOR NICOMETO A Proposal for the Development of a Hydrogel to Mimic the Cellular Microenvironment and Promote Neural Differentiation.
Personnel Director Curt R. Freed, M.D. Professor of Medicine and Pharmacology Professor of Medicine and Pharmacology Head, Div CP and Tox Head, Div CP.
Ugly.info.  It is not a single disease itself. It contains several number of brain disorders which has more severe symptoms. This classification of brain.
“HEALTH IS THE BEST” In the name of God. WHAT IS IT? Parkinson's disease (PD) is a chronic and progressive movement disorder, meaning that symptoms.
 (1) recombinant DNA technology or DNA cloning,  (2) reproductive cloning  (3) therapeutic cloning.
Neurophysiology Neuropsychiatric & Neurodegenerative disorders
Stem Cells.
Camara M1, Anscomb H.L. 2 and Baune B.T. 1,2
Volume 83, Issue 1, Pages (July 2014)
Paul M. George, Gary K. Steinberg  Neuron 
Hippocampus Cara Strong, Corinne Strong, Haneen Saed, Mackenzie Scott
Nat. Rev. Neurol. doi: /nrneurol
Diagnosing Patient #2 The two studs (you know who we are) (Zach and Jack in case you didn’t know)
Keeping ‘Trk’ of Antidepressant Actions
Nat. Rev. Endocrinol. doi: /nrendo
Blood Volume 92(10): November 15, 1998
Polydactyly L.A. Lettice, et al. Proc. Natl. Acad. Sci. USA 2002; 99(11):
How Attenuation Of Microglial Cell Using Cre-Lox Can Effect Pathology of EAE Induce Mice By Kevin Limlengco.
Therapeutic Translation of iPSCs for Treating Neurological Disease
Figure 2 Anti-LINGO-1 (Li81) does not affect cytokine production
D.P. Bartel Cell 136. Faller and Guo BBA 1779.
Levels of Organisation. YouTube Video – Levels of Organisation
Patient #2 Wilson Erwin.
Diagnosing Patient #2 The two studs (you know who we are) (Zach and Jack in case you didn’t know)
Amyloid Structures from Alzheimer’s Disease Patients
Figure 3 VEGF in neurodegenerative disease
Volume 18, Issue 2, Pages (February 2016)
The Role of Apolipoprotein E in Alzheimer's Disease
A Developmental Switch in Microglial HDAC Function
Genetic Disorder Project Example
Baseline Characteristics of the Subjects
October 3, 2013 Test next Wednesday! Table of Contents:
Amyloid Structures from Alzheimer’s Disease Patients
Targets of thiazolidinedione (TZD) drugs in Alzheimer’s disease.
Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity. Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity.
2015 January February March April May June July August September
Presentation transcript:

The Quest For The Cure of Neurological Disorders By: Devin Vides

Quest for Azheimer’s cure 1. PSR antibodies microglia 3. EPO 2. Vitamin E Clumps of amyloid NO TNF Hydrogen Peroxide eocosanoids

Stem Cell Therapy + BDNF Interestingly , despite a widespread of amyloid β and neurofibrilary tangle, the therapy created a robust enhancement of hippocampal synaptic density

Alzheimer’s video http://www.youtube.com/watch?v=zgvm_vvqq3I

Therapeutic Cloning

The Quest for a Parkinson’s cure

References Chong, Z. Z., Li, F., and Maiese K. “Employing New Cellular Therapeutic Targets for Alzheimer’s Disease: A Change for the Better?” Curr. Neurovasc Res. 2005 January; 2(1): 55-72. Jones, M. B., et al. “Neural Stem Cells Improve Cognition Via BDNF in a transgenic Model of Alzheimer Disease.” Proc Natl Acad Sci U S A. 2009 August 11; 106(32): 13594-13599. Texas Department of State Health Services . 2008. “Alzheimer’s Disease Statistics.” Retrieved on October 27, from: <http://www.dshs.state.tx.us/alzheimers/statistics.shtm>. CIRMTV. “Neural Stem Cells Reverse Alzheimer’s Like Symptoms.” Youtube video. 2009 July 28. Retrieved from: < http://www.youtube.com/watch?v=zgvm_vvqq3I>