Dynamic covalent chemistry Dynamic covalent chemistry is a strategy in chemistry in which a reversible reaction is under thermodynamic reaction control and a specific reaction product out of many possible reaction products is captured [1]. Because all the components in the reaction mixture are able to equilibrate quickly, some degree of error checking and proof reading is enabled. The concept of dynamic covalent chemistry was demonstated in the development of specific molecular Borromean rings.chemistrye reaction is underol and a specific reaction proe a

The concept is also demonstrated in a reaction sequence involving polyacetal macrocycles [2]. The cyclophane C2 can be prepared by the irreversible highly diluted reaction of a diol with chlorobromomethane in the presence of sodium hydride. The dimer however is part of series of equilibria between polyacetal macrocycles of different size brought about by acid catalyzed (triflic acid) transacetalization. This particular type of transacetalization goes by the name of formal metathesis because it is reminiscent of olefin metathesis but then with formaldehyde. Regardless of the starting material, C2, C4 or a high molar mass product, the equilibrium will eventually produce an identical product distribution. In this system it is also possible to amplify the presence of C2 in the mixture when the catalyst is silver triflate because the silver ion fits ideally and irreversibly in its cavity.polyacetals [2]. The2 cpared by tis part of ser. This particusacetalizati name of formal me a high molar maseventually ppossible t

References 1.1.↑ Dynamic covalent chemistry Rowan SJ, Cantrill SJ, Cousins GR, Sanders JK, Stoddart JF. Angewandte Chemie International Edition PubMed Abstractddart JF. Anie International Edition ↑ Metathesis reaction of formaldehyde acetals: an easy entry into the dynamic covalent chemistry of cyclophane formation. Cacciapaglia R, Di Stefano S, Mandolini L. J. Am. Chem. Soc PubMed Abstracthyde acetals: ao t