2D-NMR. COSY, CO rrellation S pectroscop Y COSY NMR/nmr/chem806/Web/homo2_files/frame.htm.

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Presentation transcript:

2D-NMR

COSY, CO rrellation S pectroscop Y

COSY NMR/nmr/chem806/Web/homo2_files/frame.htm

COSY, COrrellation SpectroscopY

2D-NMR: COSY C 5 H 10 O 2 IR: 1730 and 1200 cm -1, no peaks above 3000 cm -1

COSY: C 5 H 10 O 2

2D-NMR: COSY C 6 H 12 O 2 IR: 1730 and 1200 cm -1, no peaks above 3000 cm -1

2D-NMR: COSY

1H2H3H 21 C 4 H 9 Cl 2D-NMR: COSY

C 14 H 20 O 2 (ester) 2D-NMR: COSY

C 14 H 20 O 2 2D-NMR: COSY

Given the COSY on the next page, assign all protons and calculate coupling constants, J 23, J 24 and J 34 ? (Because of the heterocyclic ring, H-2 has the highest chemical shift and the ortho coupling constant J 2-3 ~ 4Hz, significantly smaller than a normal ortho coupling constant.

2D-NMR: COSY

Problem - Identify where the methyl is located on the quinoline Ring and assign all protons. Show correlation lines on the COSY spectrum to support your assignments.

2D-NMR 1 H- 13 C Correllation Spectroscopy (HETCOR, HMQC, HSQC)

2D-NMR 1 H- 13 C Correllation Spectroscopy (HETCOR, HMQC, HSQC) C 5 H 10 O

C4H9IC4H9I

C4H9IC4H9I COSY HMQC

Unknown: C 10 H 12 O