Waters HPLC Competitive Review

Varian 920-LC Market Competitors Shimadzu Waters Agilent Dionex The 920-LC presents a significant step forward for the Varian

Consists of two versions 2695 Separations Module Waters Alliance Consists of two versions 2695 Separations Module 2795 Separations Module Pump, autosampler, column heater and controller Wide range of Detectors 2996 Diode Array Detector 2487 Dual wavelength Detector 2475 multi-wavelength Detector 2414 RI Detector 432 Conductivity Detector 2420 ELS Detector 2465 Electrochemical Detector

Varian 920-LC Compared to Waters Alliance Maximum flowrate 5 ml/min 10 ml/min Maximum pressure Autosampler Capacity 120 HPLC vials 200 HPLC vials Microplate Capability NA 3 plates Maximum Column Heater Temp 60oC 65oC Number of Detectors None Up to 2 built-in Sample Carryover <0.1% <0.01%

Varian 940-LC Compared to the Waters Purification HPLC

Waters Delta 600 LC Analytical to Prep Delta 600 wide flow rate range and 2 way injector valve allows operation at analytical and prep scales Delta 600 LP LP dual piston quaternary gradient pump 0.01 to 20 ml/min & up to 6000 psi Up to 45 ml/min option Stand alone 2 channel degasser option recommended

PrepLC Dedicated Purification Systems PrepLC 150 and 300 Dedicated preparative LC system quaternary gradient 1 to 150 ml/min Up to 4000 psi 4 to 300 ml/min Up to 2000 psi DeltaPrep 150 and 300 Same as PrepLC but with solvent recycling capabilities

Waters PrepLC Sample Load Column ID Model Max Flow Rate (ml/min) mg – 10’s g 7.8 – 75 mm DeltaPrep 300 300 ml/min mg – g 4.6 – 50 mm DeltaPrep 150 150 ml/min mg – 10’s mg 2545 3.9 – 30 mm Delta 600 EF 45 ml/min 3.9 – 19 mm 1525 + EF 22.5 ml/min Delta 600 20 ml/min mg - g 3.9 – 7.8 mm 1525 10 ml/min

Summary of Varian 940-LC vs Waters Purification Systems Limited automation No autosampler injection capability Limited fraction collection capability Front panel control with limited S/W interaction Up to 120 test tubes or 2 Alliance Carousel racks (48 x 2 ml HPLC vials) Inflexible pumping system Need two systems to cover 4.6 mm, 21 mm and 50 mm ID columns Analytical detectors with short path flow cells Limited performance in analytical mode Or limited abs range

Waters Detectors for Prep LC

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