April 9, 2004BME 272/2731 Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements,

Slides:



Advertisements
Similar presentations
Mass Spectrometer Auto Sampler Kyle Sala Jake Ahrens Stephen Pearson Seth Yellin.
Advertisements

Blood Transfusion Nursing Procedure. *Whole blood transfusion replenishes the circulatories:  Volume  Oxygen-carrying capacity *Packed Red Blood Cells.
Principle Concepts of Iv therapy.
Bringing Solutions to Vascular Medicine ML2303 Rev A 10/10.
WETSIDE DESIGN © Copyright 2008 HVAC Design Solutions1 Essential Design Programs with Accurate Sizing Calculations help to “Streamline Your Design” Essential.
RAD 354 Chapt 22 Interventional Radiology Diagnostic Imaging Therapeutic (interventional)
P08026: Modular Hemodynamic Flow Simulator Jason Brown Mechanical Engineering Amanda Clark Mechanical Engineering Matthew Hicks Electrical Engineering.
Team Air Liquide Senior Design Project 2007 Process Improvement of Resin Application System Phase IV Group Presentation Pete John Adam Willoughby-Knox.
Automatic Home Medication Dispenser Project # P07009 Team Guide - Dr. Daniel Phillips Project Sponsor - Dr. Michel Berg Team Members Alan StrandburgChris.
Progress Report Patient Positioning Aid E. Vargas, E. Kordieh, M. Britan Department of Biomedical Engineering April 7, 2006.
MRI Infusion Pump. Advisor Dr. Naomi Chesler  Biomedical Engineering  University of Wisconsin - Madison.
Mechanical Engineers: Brian Church Tyler Breitung Michael Oplinger Electrical Engineers: Anthony Salmin Ross Bluth Stephen Mroz Sponsor: Dr. Roman Press.
Talent Management Training Methods.
Research Strategy Review: Heat Pump Water Heaters Thermostatic Restriction Valves Jennifer Anziano RTF R&E Subcommittee July 8, 2015.
CPAP Remote Alarm System BME 272: Oral Report Two Group 15 Kathleen Grunder Jessica Paulsen Molly Rice.
ZenPure 1 Microfiltration: 1. Maximizing protein recovery. 2. Complete asepsis: eliminating hose barbs and triclamps. 3. New optimal design filter for.
SYSTEM ANALYSIS AND DESIGN
1 July 2007 P48610 Rev.2 SmartInfuser PainPump ™ P49220, P49224N Operation Instructions.
Project Definition The aim of this project was to design a steerable catheter, which would enable easier access to specific blood vessels. The design would.
Introduction Topic: The Basic Ground Source Heat Pump Name: Matthew Stoangi Objective: To provide a clear understanding of the mechanics involved in the.
1 Rev: 02/12/2007 MSE-415: B. Hawrylo MSE-415: Product Design Lecture #3 Chapter 4 Identifying Customer Needs.
Prepared by: Salwa Maghrabi Teacher Assistant Nursing Department Arterial Blood Gases.
MedTG Needle Design Steve Harris Adam Travis Brett Byram Group #15 Advisors: Gary Byram, Ph.D. Paul King, Ph.D., P.E.
1 On Rate for Fuel Oil Equipment. 2 Purpose To insure that the equipment is delivering the correct heating value Oil fired equipment must fire within.
Procedure Writing Basics Mr. Richard Crisler Spring-2006.
1Abstract Our objective was to design an infusion pump that will be used to deliver contrast agents during a MRI exam. Currently used is a syringe pump.
Bloodborne Pathogens 29 CFR Components of the Standard Exposure Control Plan Methods of Compliance –Universal Precautions –Engineering and.
Multifunction IV Catheter Brett Byram 1, Steve Harris 1, Adam Travis 1 Advisors: Gary Byram, Ph.D. 2 ; Paul King, Ph.D., P.E. 1 1 Department of Biomedical.
RESEARCH.  RE·SEARCH :  Detailed study of a subject, especially in order to discover (new) information or reach a (new) understanding. Cambridge Dictionaries.
Cardiac Cath and Angiocardiography SPRING 2009 FINAL
Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll.
Computed Tomography Angiography (CTA). What is CT Angiography? An examination that uses x-rays to visualize blood flow in arterial and venous vessels.
Cauterization Catheter – An Advancement in Conductive Biomaterials and Medicine C. Blyth 1, C. Fernandez 1, S. Hittinger 1, C. Jones 1, B. McGee 1, B.
Prepared by : Salwa Maghrabi Teacher Assistant Nursing Department
CPAP Remote Alarm System BME 272: Oral Report Three Group 15 Kathleen Grunder Jessica Paulsen Molly Rice.
Alex Gee Jon Locke Joe Cooper Kylie Rhoades Clara Echavarria Ice Energy Extraction.
Design of a Steerable Catheter Steeratheter Cherry R. Abenojar Eric D. Benson Dr. Theodore Larson, Project Advisor.
What tests are necessary to make sure your kegs are being cleaned, sanitized and filled correctly By Andrew J. Brewer
Cardiac Cath and Angiocardiography Adult II FINAL 2/2015.
Experimental Control Definition Is a predictable change in behavior (dependent variable) that can be reliably produced by the systematic manipulation.
Improving Microcatheter Navigation Through the Brain Matt Kergosien Holly Bonar Advisor : Dr. Ted Larson.
Nanofluidic Characterization David Sharp David West Justin Davis.
March 24, 2004BME 272/2731 Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements,
Investigation of Bubble Formation in Tuohy-Borst Adaptors Melanie Bernard†, Isaac Clements†, and Jason Hirshburg† Advisor: Dr. Ted Larson, III, M.D.‡ †
February 4, 2004BME 272/2731 Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements,
Group 4 MGMT 580 Case Study 3.1 Shawndra Janne. Problem Statement The spray nozzles located in the parts washer are clogging, causing the parts washer.
Intravenous cannulation
Feasibility Analysis of a Two Phase Solar Thermal Water Heater Solar Thermal Solutions (M15) Project Supervisor: Dr. Y. Muzychka April 3 rd, 2014 Marcus.
Intraosseous Access with the Sternal EZ-IO ® Needle Set.
Heat Exchangers Results Josué Ortiz #57703 Prof: Eduardo Cabrera Me
Team Members: Lacey Halfen, Jessica Hause, Erin Main, Peter Strohm & Fan Wu Client: Orhan UnalAdvisor: Willis Tompkins Team Members: Lacey Halfen, Jessica.
Determine method of rapid prototyping or plastic extrusion to create prototype of true-to-scale catheter Determine optimal slot size without affecting.
January 26, 2004BME 272/2731 Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements,
Patient is placed between X-ray tube and silver halide film.
TYPES OF IMAGINE & USES. Fluoroscopy  Technique for obtaining “live” X-ray images of a living patient  What systems most commonly used for?  Often.
TC JWG 4 WI 00400 Introductory element — Energy Efficiency & Savings Calculation, Top-down and Bottom-up Methods — Complementary element Task 21 Experts.
Advisors: Gary Byram, Ph.D.
Mechanical Subsystems LabVIEW Code for Feedback Loop
Improving Simulations in the Post Anesthesia Care Unit
Alarm Sound Tutorial.
Comparison between Serrated & Notched Serrated Heat Exchanger Fin Performance Presented by NABILA RUBAIYA.
Venous uptake of Tc-99m MIBI: An exploration of possible causes
Catheter Design Cynthia Harmon Jarntip Pitayagulsarn
Coronary Phantom Design for K-edge Angiography
Problem Statement and Significance
ME321 - Kinematics and Dynamics of Machines Design Process Notes
Airway Suctioning NUR 422.
Continuous Blood Gas Monitor
Coronary Phantom Design for K-edge Angiography
Presentation transcript:

April 9, 2004BME 272/2731 Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements, & Jason Hirshburg Advisor: Ted Larson III, M.D.

April 9, 2004BME 272/2732 Problem Statement Bubbles are seen within the Tuohy-Borst Adaptor –Origin/cause unknown Consequences –Can get stuck in small arteries, inhibiting blood and oxygen to the brain –Causes stroke in 0.1% of procedures (bubbles > 1ml) Accessory Problems –Bubbled are hard to remove; they stick to inner surface of tubing/adaptor –Occurs in adaptors of different length, angle of arm –May be from multiple sources

April 9, 2004BME 272/2733 Problem Definition Find the cause of the bubbles and correct it! –Constraints Solution must apply to all adaptor types Any system changes must not significantly change adaptor cost or the catheterization procedure. Must eliminate problem without introducing new ones –Limitations Time – 6 months Money – have only a reasonable budget. Equipment – don’t have access to blood or ultra- sound machines cardio/cathlab.htm

April 9, 2004BME 272/2734 Background Dr. Larson has 15 years of experience in interventional neuroradiology Catheter uses: –Angiography –Embolization of arteriovenous fistulas –Aneurysms –Preoperative embolization of neck and intracranial tumors Bubbles are consistently observed in catheterization procedures (but have not been formally documented by Dr. Larson). Dr. Larson reverses flow 3 times without bubbles before proceeding.

April 9, 2004BME 272/2735 Background cont. Bubble Traps –Used when blood is routed outside the body with pumps Cost Analysis –$45k/procedure $25k Radiology ~4-6 min. to clear bubbles ~3 hour procedure =$700!!

April 9, 2004BME 272/2736 Market Potential Target group –Operating rooms worldwide Will meet customer needs –Catheterization procedures will be safer Is technologically feasible –Physical principles and/or methods can be changed to eliminate bubble formation Is economically viable –Adaptor costs should not rise after our changes –Could save up to $700 per procedure (not including saving money that would be lost for inducing a stroke)

April 9, 2004BME 272/2737 Primary Objective Our task is to discover the cause of bubble formation and correct it Observations from Dr. Larson’s procedures: Bubbles… –Up to 10-20% of tube diameter –Stick to inner surface of adaptor –Appear at the edge of the Y-junction –Occur before microcatheter is inserted –Typically occur when catheter flow is reversed and blood hits the edge of the Y-junction and interfaces with the saline

April 9, 2004BME 272/2738 Previous Work Observed device in a medical procedure on 11/18/03 Literature Search Innovation WorkBench (revised 3/2) Conducted experiments –Primary: tested equipment –Secondary: simulated pressures and temperatures of entire system –Tertiary: testing individual components to different conditions Filmed procedures on 2/2/04 and 3/31/04; obtained new supplies Performed calculations based on actual and worst-case scenario parameters

April 9, 2004BME 272/2739 Possible Sources of Bubbles 1. Leaks From 3-way valve From rotating hemostatic valve Between adaptor and catheter 2. Introduced during adjustments In flushing process Injecting contrast agent Reversing fluid flow 3. Adaptor Angle of arm causes local pressure drop Microbubbles pool at connections 4. Temperature differences N 2, O 2, or CO 2 coming out of blood Air coming out of saline 5. Initial flushing process In catheter In saline tube Pulling back saline syringe 6. Saline Air coming out of solution Pushed into system by pressure bag High flow rate and interaction with blood Pressure drop from 250 – 0 mmHg 7. Pressure change for N 2, O 2, & CO 2 in blood Local pressure drop at diameter change Pressure drop across catheter Pressure drop from 100 – 0 mmHg

April 9, 2004BME 272/27310 Experiments Conducted Primary Experiments: –Observed many bubbles throughout system Secondary Experiments: –Blood pressure = 120/80 (mmHg) –Saline pressure = 250 mmHg –Blood temp = 98.6 F –Saline temp = room Tertiary Experiments: –Tested connections for leaks 35 degree catheter turn –Air solubility in saline under pressure (250 mmHg) –Tested catheter for bubbles after flushing –Tested bubble occurrence after syringe pull-back

April 9, 2004BME 272/27311 Videotaping the procedures We videotaped the bubble phenomenon during two actual procedures in Dr. Larson's operating room: The first videotape was created on 2/24/04 with a standard VHS video camera. We acquired a high resolution digital video camera to videotape a second procedure on 3/31/04.

April 9, 2004BME 272/27312 Videotape Analysis Observations: There are many bubbles forming! Out of 4 minutes of footage, we recorded 15 bubble occurrences. Bubbles appear to be coming from within the catheter In 14 out of 15 cases, the bubbles appear under set conditions: 1.Saline is flowing forward into the catheter 2.The 3-way valve is opened and flow is reversed 3.Bubbles appear immediately and seem to be coming from within the catheter.

April 9, 2004BME 272/27313 Current & Future Work In a meeting with Dr. Larson, we laid out our final goals for the project, including: –Determining all possible sources of bubbles –Ruling out as many as possible through our observations, calculations, and experiments. –Taking the remaining possibilities and determining the likelihood of each theory. –Create a final analysis of the most likely cause. –Give suggestions for improving the situation. We have researched the following catheter clearing methods: –Wetting agents –Dynamic Bubble Traps (DBTs) –Degassing saline before injection (and heat?)

April 9, 2004BME 272/27314 Acknowledgements Dr. Ted Larson and staff Dr. Paul King Dr. Joan Walker Dr. Robert Roselli Dr. Todd Giorgio Dr. Cynthia Paschal Dr. Rick Haselton Dr. Bob Galloway Matt Lytle for his services as cameraman. We would like to thank the following professionals and experts for their input:

April 9, 2004BME 272/27315 Bibliography Catheter Flushing, Bubble Formation within Catheters, Dynamic Bubble Traps, Wetting Agents: Manufacturing Links for Tuohy-Borst Adaptors: Images for Catheter Insertion Procedure: Interventional Neuroradiology Links:

April 9, 2004BME 272/27316 Questions…? Visit our website at 5_06/5_06_06.html