Cartilage and Bone Robert Scranton© 2008

Cartilage Few or many cells? Cell name? Vascular? The dense CT covering is _________, except for around __________ Matrix-  CT+ ground substance  Collagen, type___  GAG= “keratin/ chondroitin sulfate  Chondronectain  Bound water  Territorial v. interterritorial

Cartilage Perichondrium Define it  dense CT covering all cartilage but articular Layers Functions:  Nutrition  Growth  Repair  Attachment point

Cartilage Word Games Cell nests Perichondrial growth Hypertrophy Alkaline phosphatase v. hydroxyapatite crystals Fibrillin +elastin

Cartilage Types Hyaline, elastic, fibro  Give location, characteristics TypeLocationCharacteristics Hyalinearticular, larynx, trachea, bronchi, costal Type II Collagen, GAGs, chondronectin, bound water Elasticauricles, ext. auditory tube, eustachian tube, epiglottis like hyaline, but with elastic fibers FibroIntervertebral disks, pubic symphysis, TMJ like dense irregular CT, Collagen type I&II, very little ground substance

Cartilage Hyaline

Cartilage Hyaline

Cartilage Elastic

Cartilage Fibro

Cartilage Example of Articular Cartilage

Bone Epiphysis Diaphysis Metaphysis (in growing child) Epiphysis

Bone Word Games Compact bone= ____bone Cancellous bone= ____ bone and has ___ which are _____ The space b/w trabeculae and spicules filled with hematopoietic or fatty tissue. Diploe Immature bone, give syn.  Found during Secondary Bone Osteon

Bone Periosteum & Endosteum Periosteum, how many layers?  2- fibrous +osteogenic  How does it attach to bone?  Sharpey’s fibers=  Function?  Appositional growth  Repair  Attachment for ligaments and tendons  sensation

Bone Periosteum & Endosteum Endosteum, how many layers?  What type of cells?  osteoblasts

Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Matrix

Bone Name the major players  Osteoblasts  Active, mitotic  Osteocytes  Osteoclasts  Matrix

Bone Name the major players  Osteoblasts  Osteocytes  Surrounded by matrix  Can’t divide  Lacunae & canaliculi  Osteoclasts  Matrix

Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Derived from?  Function?  Located in?  Synthesize and secrete?  Matrix

Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Derived from?  Function?  Located in?  Synthesize and secrete?  Matrix

Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Matrix  Inorganic> Organic  Inorganic- hydroxyapatite, rigidity  Organic- Type I collagen, GAG, elasticity  Bone is vascular

The Haversian System

The Volkmann’s Canal

The Haversian System

Haversian Canal Volkmann’s Canal Bone

Hormone Effects

Don’t neglect Section on Spongy Bone Joints  What is the origin of the secretory epithelial lining the joint space