Biologic Monitoring A. H. Mehrparvar, MD Occupational Medicine department Yazd University of Medical Sciences.

Slides:

Advertisements

Similar presentations

HYGIENE STANDARDS AND OCCUPATIONAL EXPOSURE LIMITS

Advertisements

PERSONALIZED MEDICINE: Planning for the Future You, Your Biomarkers and Your Rights.

Battlement Mesa Health Impact Assessment and Exposure/Health Study Stakeholders Meeting Roxana Witter, MD, MSPH John Adgate, PhD, MSPH Lee Newman, MD,

1 Aflatoxin exposure, health impacts, risk assessment and database Aflatoxin Stakeholders’ Workshop 3-4 December, 2012 Dar es Salaam, Tanzania.

William H. Farland, Ph.D. Acting Deputy Assistant Administrator for Science Office of Research and Development U.S. ENVIRONMENTAL PROTECTION AGENCY Biomarkers:

Biomonitoring ….a dialogue EnviroCancer Connections-LDL February 14, 2005 Discussion Leader: Suzanne Snedeker - BCERF.

Biomarkers and Risk Assessment for Chromium(VI) Qingshan Qu, MD (PI) Roy Shore, PhD (Co-I) Dept. of Environmental Med. NYU School of Medicine.

University of Turku Department of Biochemistry Jukka-Pekka Suomela Biomarkers.

Environmental Health III. Epidemiology Shu-Chi Chang, Ph.D., P.E., P.A. Assistant Professor 1 and Division Chief 2 1 Department of Environmental Engineering.

Biostatistics Frank H. Osborne, Ph. D. Professor.

Copyright 2002 Marc Rigas Issues in Exposure Assessment Marc L. Rigas, Ph.D. National Exposure Research Laboratory, U.S. Environmental Protection Agency.

What Do Toxicologists Do?

Introduction of Cancer Molecular Epidemiology Zuo-Feng Zhang, MD, PhD University of California Los Angeles.

Biomedical research methods. What are biomedical research methods? An integrated approach using chemical, mathematical and computer simulations, in vitro.

NORA Exposure Assessment Methods Team Whitepaper Research Needs and Priorities Beth Donovan Reh National Institute for Occupational Safety and Health (NIOSH)

Luděk Bláha, PřF MU, RECETOX BIOMARKERS AND TOXICITY MECHANISMS 13 – BIOMARKERS Summary and final notes.

Supercourse Environmental Exposure Assessment And Biomarkers Wael Al-Delaimy, MD, PhD.

BIOLOGIC MARKERS IN OCCUPATIONAL AND ENVIRONMENTAL MEDICINE By: Dr Chavoshi.

Zuo-Feng Zhang, MD, PhD Epi242, Prospective:  Cohort Studies: Observational studies  Intervention Studies, Clinical Trials  Nested Case-Control.

General Pathology (1 credit hour theory) The following percentages (%) of the total grade will be assigned: In-Course Assessments ………………………..………60.

A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication A substance used in the diagnosis, treatment,

Environmental • failure analysis & prevention • health • technology development A leading engineering & scientific consulting firm dedicated to helping.

Luděk Bláha, PřF MU, RECETOX BIOMARKERS AND TOXICITY MECHANISMS 11 – BIOMARKERS of EXPOSURE and SUSCEPTIBILITY.

INTRODUCTION TO TOXICOLOGY SIDNEY GREEN, PH.D. DEPARTMENT OF PHARMACOLOGY COLLEGE OF MEDICINE HOWARD UNIVERISTY.

Clinical Pharmacy Part 2

1 Environmental Epidemiology on small areas Ph. D. Alessandro Menegozzo Agenzia Regionale Prevenzione Protezione Ambientale Veneto ( Italy )

Orientation to Pharmacology

Animal Studies and Human Health Consequences Sorell L. Schwartz, Ph.D. Department of Pharmacology Georgetown University Medical Center.

Luděk Bláha, PřF MU, RECETOX BIOMARKERS AND TOXICITY MECHANISMS 10 – BIOMARKERS Introduction.

Bioavailability Dr Mohammad Issa.

Biomarkers Biomarkers - markers in biological systems with a sufficently long half-life which allow location where in the biological system change occur.

FARMAKOKINETIKA. INTRODUCTION Historically, pharmaceutical scientists have evaluated the relative drug availability to the body in vivo after giving a.

The science that deals with the recognition, evaluation and control of hazards in workplaces in order to prevent illness among employees. ?

International Atomic Energy Agency Assessment of Internal Exposure following Accidents or Incidents ASSESSMENT OF OCCUPATIONAL EXPOSURE DUE TO INTAKE OF.

FUNDAMENTALS OF OCCUPATIONAL TOXICOLOGY Vesa Riihimäki, MD, PhD, MSc Finnish Institute of Occupational Health.

Pollution and Human Health

Biopharmaceutics refers to the relationship of the:

CHEE 4401 Definitions drug - any substance that affects the structure or functioning of an organism pharmaceutics - the area of study concerned with the.

Diagnostic Tests Afshin Ostovar Bushehr University of Medical Sciences Bushehr, /7/20151.

AIDS in the workplace AH Mehrparvar,MD Occupational Medicine department Yazd University of Medical Sciences.

Biological monitoring

Introduction to Clinical Chemistry MLCC-203 Department of Medical Laboratory Technology Faculty of Allied Medical Science By Dr. Eman El-Attar.

CHAPTER ONE CHAPTER ONE INTRODUCTION TO PATHOPHYSIOLOGY. BY: BY: Dr. Uche Amaefuna-Obasi (MD).

INTRODUCTION CLINICAL PHARMACOKINETICS

Timing of exposure assessment in relation to exposure occurrence:  Historical or retrospective: i.e., exposure reconstruction; an attempt to identify.

PRINCIPLES OF TOXICOLOGY...a discussion of the fundamental means by which toxicological properties are determined.

2-1-1 Introduction to the Biochemical Testing Program Enabling Learning Objectives 1.Select from a list the definition of biochemical testing. 2.Select.

NUATRC/TCEQ Air Toxics Workshop October Air Toxics Air Toxics: What We Know, What we Don’t Know, and What We Need to Know Human Health Effects –

By: Gh. Pouryaghoub. MD Center for Research on Occupational Diseases (CROD) Tehran University of Medical Sciences (TUMS)

Introduction to Pharmacology Yacoub Irshaid MD, PhD, ABCP Department of Pharmacology.

1 Biopharmaceutics Dr Mohammad Issa Saleh. 2 Biopharmaceutics Biopharmaceutics is the science that examines this interrelationship of the physicochemical.

An Introductory Lecture to Environmental Epidemiology Part 4. Some Issues in Exposure Assessment Mark S. Goldberg INRS-Institut Armand-Frappier, University.

HEX-Tox paper reading Tue Hye Young Choi.

Introduction about Nutritional Assessment methods

Manganese Biomonitoring for assessment of Exposure to Airborne Manganese in Foundry Plants Dr. Seyedtaghi Mirmohammadi Assistant Professor. Indoor Air.

A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication recognized or defined by the U.S. Food, Drug,

Jerrold J. Heindel PhD Acting Chief Cellular Organ and Systems Pathobiology Branch National Institute of Environmental Health Sciences National Institutes.

INTRODUCTION TO BIOCHEMISTRY By Dr. Mohammed Golam Rasul COLLEGE OF DENTISTRY MAJMAAH UNIVERSITY.

Biologic Monitoring A. H. Mehrparvar, MD

HYGIENE STANDARDS AND OCCUPATIONAL EXPOSURE LIMITS

10 – BIOMARKERS Introduction

General Toxicology General Considerations in Toxicology Lec

Biopharmaceutics Dr Mohammad Issa Saleh.

Biological monitoring

Learning Objectives. Advances in the Screening and Treatment of WTC Responders and Survivors.

Assessing Bias 1.

Journal reviews 이승호.

Chapter 1 Introduction of Pharmacology [,fɑ:mə'kɔlədʒi] 药理学

OCCUPATIONAL LIVER DISEASES

INTENTIONAL HUMAN DOSING STUDIES (IHDS)

Presentation transcript:

Biologic Monitoring A. H. Mehrparvar, MD Occupational Medicine department Yazd University of Medical Sciences

Introduction  Environmental monitoring vs biologic monitoring  Prediction of biologic levels by environmental monitoring  Sources of variability: Different sources of exposure RR Rate of metabolism and excretion Adipose tissue level PPD

Introduction  Assesses the extent of exposure  Indirectly assesses health effects  Probability of illness, never diagnostic  Abnormal biologic monitoring levels: Multiple measurements  Timing of collection very important: DS, EOS, EWW, PNS

Biologic monitoring program  Necessary conditions: Determinant Method of analysis Sample collection Interpretation of results Responding action  Sufficient conditions: Environmental monitoring  Conducted  Not adequate  Not feasible Substances Exposure routes

Biomarkers  Biologic marker or biomarker: any substance, structure or process that can be measured in the human body or human body products, and may influence or predict disease Biologic monitoring: Measuring a chemical, its metabolite or its non-adverse effect in a tissue sample in order to monitor exposure

Biomarkers (cont.)  Classification:  Biomarker of exposure  Biomarker of effect  Biomarker of suceptibility

Biomarker of exposure  Biomarker of internal dose Blood lead Urine Mn  Biomarker of effective dose CoHgb

Biomarker of exposure (cont.)  Characteristics:  Correlation with exposure  Correlation with target tissue dose  Reversibility  Appropriate sampling method

Biomarker of effect  Measurement of reversible biochemical changes after an internal dose  Not pathological effects  Example: inhibition of δ-ALA by lead

Biomarker of susceptibility  Possible differences between individuals in responding to an exposure