The Mouse Bioinformatics Research Network (MBIRN) Cal Tech- Russ Jacobs Duke- G. Allan Johnson Mike Fehnel UCLA- Art Toga UCSD- Mark Ellisman Maryann Martone.

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Presentation transcript:

The Mouse Bioinformatics Research Network (MBIRN) Cal Tech- Russ Jacobs Duke- G. Allan Johnson Mike Fehnel UCLA- Art Toga UCSD- Mark Ellisman Maryann Martone

Goals The unique challenges of MBIRN Representative collaborations The value of connections

MBIRN- a heterogeneous data collection Images MR,optical,EM Regulatory IACUCC, FundingAgency Project Description Goals,Literature,Design Specimen Age,Weight,Sex,Genotype Experimental TR/TE,Resolution, Special Stains Analysis Segmentation,volumes,visualization Behavioral Data (future)

Collaborations Shiverer UCLA,Cal Tech, UCSD,Duke Alpha-synuclein overexpressor UCSD,Duke DAT/KO, Rheeler MBIRN- MorphBIRN Astrocytoma UCSD UNC Duke

Alpha-SYN aggregates in brains of tg mice Diana Price Natalie MacLean ~0.5 TB

Alpha-synuclein Mouse Diana Price, UCSD

Actual Diffusion Restriction Tensor Model Diffusion Tensor Model of Restricted, Anisotropic Diffusion Caltech 2004 Tyszka & Jacobs

3D DTI Shiverer Mouse CNS +/+ CNS shi/shi Naturally occurring mutant- a model of demyelating disease Myelin basic protein (MBP) gene deletion. Virtual absence of compacted myelin in CNS, but not PNS. Motor tremors, seizures and significantly reduced lifespan (approx 90 days). Caltech 2004 Tyszka & Jacobs

FA[D] Mean Fractional Anisotropy (Control) Caltech 2004 Tyszka & Jacobs 3D Diffusion Tensor 7 512x256x Gb

FA[D] Mean Fractional Anisotropy (Shiverer) Caltech 2004 Tyszka & Jacobs 3D Diffusion Tensor 7 512x256x Gb

Summary

Image Registration

Brain Morphology in DAT-KO Mice Aki Laakso, Ph.D., Duke University 3D reconstruction of caudate-putamen and ventricles

P<0.001n.s. Two-way repeated measures ANOVA Profile of caudate-putamen in DAT-KO mice:

Stereological cell counts Same brains that were used for MRI Striatum divided into anterior and posterior parts, based on MRH profile analysis All nuclei:Neuronal nuclei:

Brain Morphology in DAT-KO Mice Michel Cyr, Ph.D., Duke University

Reeler Mouse MBIRN-MorphBIRN William Wetsel, Duke

Connections Man Mouse Celllar Subcellular MBIRN Morph BIRN fMRI BIRN NCRR Resources International Research Community Tools Data Ideas People