Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model by M. L. Bouxsein, T. J. Turek, C. A. Blake, D. D’Augusta,

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Presentation transcript:

Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model by M. L. Bouxsein, T. J. Turek, C. A. Blake, D. D’Augusta, X. Li, M. Stevens, H. J. Seeherman, and J. M. Wozney J Bone Joint Surg Am Volume 83(8): August 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

In vivo (left panel) anteroposterior and mediolateral (middle panel) radiographs and representative histological section (right panel) showing the site of the ulnar osteotomy. M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83: ©2001 by The Journal of Bone and Joint Surgery, Inc.

Graph depicting the retention of rhBMP-2 at the ulnar osteotomy site, expressed as a percentage of the initial dose delivered (left axis) and as the absolute amount of protein remaining (right axis). M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83: ©2001 by The Journal of Bone and Joint Surgery, Inc.

Graphs showing the effect of absorbable collagen sponges (ACS) containing rhBMP-2 on failure torque (A), torsional stiffness (B), and energy absorbed to failure (C), expressed as percentages of the values for an intact limb. M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83: ©2001 by The Journal of Bone and Joint Surgery, Inc.

Representative histological sections of the ulnar osteotomy site at three weeks (top row), four weeks (middle row), and six weeks (bottom row). M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83: ©2001 by The Journal of Bone and Joint Surgery, Inc.