Joe Pekny, Professor Chemical Engineering Director, e-Enterprise Center Discovery Park Marietta Harrison, Professor Medicinal Chemistry & Molecular Pharmacology.

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Presentation transcript:

Joe Pekny, Professor Chemical Engineering Director, e-Enterprise Center Discovery Park Marietta Harrison, Professor Medicinal Chemistry & Molecular Pharmacology Director Oncological Sciences Center Discovery Park

Cancer Care Engineering

An Interdisciplinary A Multidisciplinary A Transdisciplinary

MEGA Project The Grand Societal Challenge of….. CANCER

Discovery Park Addresses GRAND CHALLENGES

Cancer Care Engineering Collaboration between…

Discovery Park is home to Large Scale Interdisciplinary Projects

Cancer Care Engineering Goal: To dramatically increase the success of cancer treatment and the effectiveness of cancer care using Indiana as a model for the nation How: Create an engineering “Systems Analysis” model for cancer detection, treatment and care delivery

CCE Strategy Indiana Cancer Care Understand Goal Oriented Improvement Model, Analyze, Communicate System Awareness Decision Support Tools CCE Hub Animal Models

The Integrated Pillars Mathematical Models Patient OMIC Analysis Health Services Research Cancer as a Managed Disease Cancer Care System Projects The Integrated Hierarchy Cancer Care Best Practice Projects Physician Tools Projects OMICS Projects

Modeling the Indiana Cancer Care System: A What-If Tool for the Big Picture Regulatory Agents Organizational & Regulatory Agents Patient Agents CRC Care System Indiana Cancer Care System Indiana Cancer Care Model What If Questions validate data What is the impact of screening rate improvement? Caregiver Agents What is the best strategy for using OMICS advances? What is the best strategy for colonoscopy screening? How can all patients with colonoscopy orders to follow-up get them? What resources are required?

Patient Blood Genomic Analysis Lipidomic Metabolomic Glycoproteomic Colon Cancer Predictive Molecular Signatures

Cancer Care Engineering Model: integrated “omics” analysis No DiseaseCancer BLOOD Genomics Proteomics Metabolomics Predictive Molecular Signature Lipidomics

CCE Integrates Faculty, Schools, and Organizations To Accelerate Effective Solutions to Treating Cancer and, Ultimately Preventing Cancer Targeted Research – Aim Research at Barriers to Success Vanguard Project for Personalized Medicine Cancer Care Engineering Would Not Exist Without Discovery Park