CardioInspect Diagnostic and Monitoring Systems for Congestive Heart Failure (CHF) Patients TAU Future Technology Development L.P.

Voltage Measurement Unit Control and Acquisition Unit The Technology EIT – Electrical Impedance Tomography Electrical Impedance tissue property is imaged non invasively Chest belt with disposable electrodes Current Source Unit Voltage Measurement Unit Control and Acquisition Unit Reconstruction Algorithm

CardioInspect Standalone Prototype Clinical Trials

Clinical Results Monitoring Lung Edema Level Improvement +16% +35% Lung Resistivity [Ohm*cm] Measurement # Significant increase in resistivity values reflect improvement of lung fluid level

The Telemedicine Home System Recording Phase Transmitting Phase Clinical data as received at the medical center

The Telemedicine Home System Healthy Subject CHF Patient

Diagnostic and Monitoring EIT System for Osteoporosis

Vision Statement Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and at home by introducing an EIT based technology that can be integrated within a hand wristband

Proposed Solution Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution: Inexpensive relative to other existing techniques Does not utilize ionizing radiation and well suited for long-term tracking that is often required in Osteoporosis management Utilized using simple and compact hardware; Can be applied in small clinics and at home Utilizing EIT: Provides information about the spatial electrical conductivity distribution within the human body Based on applying small magnitude alternating electric currents to the body and measuring developing electric potentials on the body surface The large variation in bone tissue electric and dielectric properties during Osteoporosis, makes EIT a promising technique for monitoring and diagnosing Current Source Unit Voltage Measurement Unit Control and Acquisition Unit Reconstruction Algorithm

Technical Background (1 of 4) Mathematical Formulation Forward formulation - Calculation of the spatial electrical potential due to known current sources and conductivity distribution Inverse formulation - Calculation of the spatial conductivity distribution due to known current sources and surface voltages

Technical Background (2 of 4) The Newton-Raphson algorithm Initial Guess - 0 Forward Solver Calculated surface potentials Measured surface potentials Cost function < yes End no k+1=k+k+1

Technical Background (3 of 4) Numerical computational simulation Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD

Technical Background (4 of 4) Preliminary real measurements using the developed prototype The prototype during measurement Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis Good correlation was obtained between the measured impedance and age