PHARMACEUTICS- IV (PHT 414 ) Dr. Mohammad Khalid Anwer SALMAN BIN ABDUL AZIZ UNIVERSITY COLLEGE OF PHARMACY L111/16/2016

Biopharmaceutics Biopharmaceutics is the science that examines the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption. L121/16/2016

Scheme demonstrating the dynamic relationship between the drug, the drug product, and the pharmacologic effect. L131/16/2016

Studies in biopharmaceutics use both in-vitro and in- vivo methods. In-vitro methods are procedures employing test apparatus and equipment without involving laboratory animals or humans. In-vivo methods are more complex studies involving human subjects or laboratory animals. L141/16/2016

biopharmaceutics involves factors that influence: (1) the stability of the drug within the drug product. (2) the release of the drug from the drug product. (3) the rate of dissolution/release of the drug at the absorption site. (4) the systemic absorption of the drug. L151/16/2016

Pharmacodynamics Pharmacodynamics is the study of what a drug does to the body. Pharmacodynamics is the study of the relation of the drug concentration or amount at the site of action (receptor) and its pharmacologic response. L161/16/2016

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 Pharmacokinetics is the study of what the body does to a drug.  Pharmacokinetics is the science of the kinetics of drug absorption, distribution, and elimination (ie, excretion and metabolism).  The description of drug distribution and elimination is often termed drug disposition. L181/16/2016

ADME Absorption Distribution Metabolism Excretion Elimination L191/16/2016

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