Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome Bayu Lestari

What will be Impaired in This Patient? Insulin Resistance? Dyslipidemia? (High TG, High LDL, Low LDL) T2DM? Metabolic Syndrome Obese

Background High prevalence of metabolic syndrome: relation between glucose and lipid metabolism Various clinical manifestations: T2DM, obese, dyslipidemia New therapeutic approach required for efficient and high efficacy AMPK was reported as potent molecular target for metabolic syndrome therapy

Aim Discuss about Metabolic Syndrome Discuss about AMPK as molecular target for therapy

Metabolic Syndrome Cluster of syndrome: insulin resistance, high blood glucose, dyslipidemia, obese Impairment both glucose metabolism and lipid metabolism Correlation between glucose and lipid metabolism?

Glucose Transport and How Insulin Resistance Occur

How Lipid Disorder Affect Insulin Resistance

Structure of AMPK

Activation Pathway of AMPK

Regulation of AMPK

How AMPK Activation Reduce Metabolic Syndrome

Role AMPK on GLUT4 Enhanced translocation of GLUT4 Enhanced expression of GLUT4 gene (Zheng et al, 2009) Insulin independent pathway?

mTOR Pathway

Role AMPK in Insulin Sensitivity Insulin-mTOR pathway  activation & phosphorylation S6 kinase I, down-regulation insulin receptor substrate-1 (IRS1) decrease insulin signalling (Zheng et al, 2009)

Role AMPK in Mitochondrial Biogenesis AMPK activation  improve mitochondrial function via expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1α (PGC-1α)  reduce insulin resistance  reduce development of T2DM (Zheng et al, 2009)

Role AMPK in Lipid Metabolism Lipid Oxidation Lipogenesis

Conclusion Metabolic syndrome: cluster of syndromes (insulin resistance, dyslipidemia, obese) AMPK has beneficial role as molecular target for metabolic syndrome’s therapy

Thank You