The Un-CV

Results We were unable to identify any randomised controlled trials of parachute intervention. Conclusions As with many interventions intended to prevent ill health, the effectiveness of parachutes has not been subjected to rigorous evaluation by using randomised controlled trials. Advocates of evidence based medicine have criticized the adoption of interventions evaluated by using only observational data. We think that everyone might benefit if the most radical protagonists of evidence based medicine organized and participated in a double blind, randomized, placebo controlled, crossover trial of the parachute.

Results We were unable to identify any randomised controlled trials of parachute intervention. Conclusions As with many interventions intended to prevent ill health, the effectiveness of parachutes has not been subjected to rigorous evaluation by using randomised controlled trials. Advocates of evidence based medicine have criticized the adoption of interventions evaluated by using only observational data. We think that everyone might benefit if the most radical protagonists of evidence based medicine organized and participated in a double blind, randomized, placebo controlled, crossover trial of the parachute.

Penicillin

Mean RDA = 2.0 liters Mean MDR = 1.5 liters

Obvious facts If: an astronaut needs 2 liters/day 4 astronauts travel to Mars 4 astronauts travel to Mars the roundtrip is 2.5 years the roundtrip is 2.5 years Then: we need ~7 tons of water...or do we???

NASArecyclesNASArecycles

Recycling When water is recycled, the key fact is not the daily usage, but the rate and efficacy of recycling.

Perhaps we reverse “… the signs and symptoms… ”

…but can we reverse aging itself?

Yes

Recycling When water is recycled, the key fact is not the daily usage, but the rate and efficacy of recycling.

Repair When cells are repaired, the key fact is not the daily damage, but the rate and efficacy of cell repair.

Controlling the rate of repair? Telomere length

Controlling telomere length? Telomerase

Controlling telomerase? hTERT

Controlling hTERT? ???

Recent events Drug libraries Candidates A botanical Nutriceuticals First human trial It WORKS

… decrease in biological age...