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Mapping the Auditory System in Rhesus Monkeys NIMH, July 2002 University of Iowa Neuroscience Program The University of Iowa Department of Psychology Behavioral and Cognitive Neuroscience

Auditory cortex Unfolded view of supratemporal plane and adjoining STG. Belt Parabelt Core Kaas and Hackett, PNAS 2000

Auditory Projection System Lower Brainstem Lower Brainstem IC MGB IC Early Auditory Areas MGB Early Auditory Areas

Auditory Projection System Lower Brainstem Lower Brainstem IC MGB IC Early Auditory Areas MGB Early Auditory Areas Corpus Callosum, Anterior & Posterior Commissures Tectal Commissures

Lower Brainstem Lower Brainstem MGB Early Auditory Areas MGB Early Auditory Areas Forebrain Comm. Tectal Comm. IC Intact side 'Deaf' side

Methods Speakers  2-DG injected intravenously  Monkey listens passively for 45 min  Wide variety of acoustic stimuli  Brain prepared for autoradiography  LCGU measured in ROIs throughout brain  ROIs compared for hemispheric asymmetries  Three surgically prepared monkeys

2 DG in Intact (left) and Deafferented (right) Hemisphere Early auditory areas MGB IC

Columns of 2-DG activation in rSTG

Metabolic Mapping of Visual Cortex

Metabolic Mapping of Auditory Cortex

Overlap of Auditory and Visual Maps

Auditory and Visual Processing Streams

Parabelt projections to prefrontal cortex Romanski et al., Nature Neuroscience, 1999

Left HemisphereRight Hemisphere Superior Temporal Gyrus (STG) (n=7 monkeys) % of Whole Brain Activity Monkey Vocalizations Complex Sounds and Vocalizations Complex Sounds No Vocalizations Ambient Background Sound Human Vocalizations

High Low

High Low

Monkey Vocalizations p<0.001 * Complex Sounds and Vocalizations p<0.01 * FDG Activity in the Dorsal Temporal Pole Ambient Background Noise % of Whole Brain Activity Left HemisphereRight Hemisphere

Monkey Vocalizations p<0.001 * Complex Sounds and Vocalizations p<0.01 * FDG Activity in the Dorsal Temporal Pole Ambient Background Noise Left HemisphereRight Hemisphere Complex Sounds No Vocalizations % of Whole Brain Activity