The Pain Market: Spain Core Therapeutic Report National Health and Wellness Survey 2010

2 Method and Sample  Data Collection + Survey administered via the Internet since Data collected during March-May Countries: Spain  Sample + Adults 18+ years of age + Sample drawn from the Internet panel maintained by Lightspeed Research + Invitations to participate sent to a sample stratified according to: –Gender –Age  Results are projected to reflect the total population using known population incidences for key subgroups + Weighting Variables: Gender and age + From the International Data Base of the U.S. Census Bureau and Organization for Economic Cooperation and Development

3 SampleSpain Population (n) Projected Number of Spain Adults Total Spain Adults 5, M Experiencing Pain (in the past month)* M Severe K Moderate M Mild M Severe: Rx81572 K OTC ‡ Only10 †† 73 K Untreated9 †† 68 K Moderate: Rx M OTC ‡ Only K Untreated91622 K Mild: Rx77551 K OTC ‡ Only81549 K Untreated56374 K Spain Sample Size Key segments of the Pain market are represented by the following sample sizes: †† Caution: extremely small base size ‡ OTC/Herbal Products *Excludes dental problems, headache, menstrual pain or migraine only.

Spain Pain Prevalence †† Base too small to project to total population (n<15) ‡ OTC/Herbal Products Questions reference for this slide include: HH10, HH20, PN5, PN15, PN20, PN95, PN120, DB40 (See Appendix) *Excludes dental problems, headache, menstrual pain or migraine only. Experiencing Pain (in the past month)* 6.1 M (17%) (n=868) SEVERE 714 K (12%) (n=100) Use Rx 572 K 80% (n=81) OTC ‡ Only 73 K 10% (n=10 †† ) Untreated 68 K 10% (n=9 †† ) MODERATE 3.9 M (64%) (n=554) Use Rx 2.6 M 66% (n=357) OTC ‡ Only 710 K 18% (n=106) Untreated 622 K 16% (n=91) MILD 1.5 M (24%) (n=214) Use Rx 551 K 37% (n=77) OTC ‡ Only 549 K 37% (n=81) Untreated 374 K 25% (n=56) Total Spain Adults Population 35.4 M (n=5,039)

All OTC ‡ Users 191 K (27%) (n=26 † ) Total Use Rx 572 K 80% (n=81) Spain Pain Brand Usage 2010 Experiencing Pain (in the past month)* 6.1 M (17%) (n=868) SEVERE 714 K (12%) (n=100) *Excludes dental problems, headache, menstrual pain or migraine only. ‡ OTC/Herbal Products † Caution: small base (n<30) †† Base too small to project to total population (n<15) Questions reference for this slide include: HH10, HH20, PN5, PN15, PN20, PN30, PN95, PN100, PN120, DB40 (See Appendix) 5 Specific Rx Therapies Used (By Class of Drug) Strong Opioids †† (n=12 † ) Weak Opioids294 K51%(n=39) NSAIDs362 K 63%(n=52) COX-2s †† (n=7 † ) Anticonvulsants155 K 27%(n=23 † ) Amitriptyline †† (n=0 † ) Analgesics †† (n=14 † ) All Other Pain Medications †† (n=4 † ) Top OTC ‡ Therapies Used (Unaided) Ibuprofen Products †† (n=13 † ) Acetaminophen / Paracetamol †† (n=2 † ) Aspirin Products †† (n=0 † ) Diclofenac †† (n=0 † ) Others (inc. combination OTCs ‡ ) †† (n=10 † ) MODERATE 3.9 M (64%) (n=554) Total Use Rx 2.6 M 66% (n=357) Total OTC ‡ Users 1.3 M (32%) (n=180) MILD 1.5 M (24%) (n=214) Total Use Rx 551 K 37% (n=77) Total OTC ‡ Users 620 K (42%) (n=91) Specific Rx Therapies Used (By Class of Drug) Strong Opioids †† (n=3 † ) Weak Opioids 1.1 M43%(n=143) NSAIDs 1.8 M 71%(n=261) COX-2s 126 K 5%(n=20 † ) Anticonvulsants 245 K 10%(n=34) Amitriptyline †† (n=0 † ) Analgesics 351 K 14%(n=55) All Other Pain Medications †† (n=13 † ) Specific Rx Therapies Used (By Class of Drug) Strong Opioids †† (n=0 † ) Weak Opioids126 K23%(n=18 † ) NSAIDs418 K 76%(n=60) COX-2s †† (n=2 † ) Anticonvulsants †† (n=2 † ) Amitriptyline †† (n=0 † ) Analgesics †† (n=5 † ) All Other Pain Medications †† (n=3 † ) Top OTC ‡ Therapies Used (Unaided) Ibuprofen Products824 K66%(n=124) Acetaminophen / Paracetamol406 K32%(n=59) Aspirin Products187 K 15%(n=23 † ) Diclofenac †† (n=5 † ) Others (inc. combination OTCs ‡ )621 K 50%(n=93) Top OTC ‡ Therapies Used (Unaided) Ibuprofen Products392 K63%(n=59) Acetaminophen / Paracetamol167 K27%(n=26 † ) Aspirin Products128 K 21%(n=18 † ) Diclofenac †† (n=3 † ) Others (inc. combination OTCs ‡ )292 K 47%(n=44) Total Spain Adults Population 35.4 M (n=5,039)

6 Experiencing Pain in Past Month* Total Rx Users Strong Opioids Weak OpioidsNSAIDsCOX-2s AntiConv- ulsants Amitri- ptylineAnalgesics All Other Pain Medication 3.7 M125 K1.5 M2.6 M182 K412 K0 K488 K144 K (n=515)(n=15 † )(n=200)(n=373)(n=29 † )(n=59)(n=0 †† )(n=74)(n=20 † ) Duration of Rx Usage (mean # of months) Experiencing Pain (in the past month)* Severe Moderate Mild % Extremely/Very Satisfied Experiencing Pain (in the past month)* 40% 31% 43%37%46%-45%52% Severe 32% 39%29%28%31%33%-28%79% Moderate 40% -32%43%40%51%-47%23% Mild 55% -21%59%31%100%-84%100% # Days/Mo. Report Taking Rx (mean) Experiencing Pain (in the past month)* Severe Moderate Mild % Requested Specific Rx Experiencing Pain (in the past month)* 29% 25%26%28%14%11%-29%26% Severe 27% 24%30%26%17%16%-33%46% Moderate 28% 26%22%27%10%9%-27%24% Mild 36% -45%35%44%--40%17% Pain Prescription Medication Usage (Experiencing Pain and using Rx)* *Excludes dental problems, headache, menstrual pain or migraine only.Caution: † small base size; †† extremely small base size *Note: mean satisfaction taken into consideration if multiple pain therapies are used. PN35: You indicated you use the following prescription medication(s). Did you request this specific brand from your doctor?. PN40: How many years and/or months have you been using these prescription medication(s)? If you have been using it less than 1 month, please enter a “0” for ”years” and “1” for “months”. PN45: How many days did you use these prescription medication(s) in the past month? PN50: How satisfied are you with these prescription medication(s)? Based on 7 point scale where 1=Extremely dissatisfied and 7=Extremely satisfied In 2010, a "stacked" method was used for determining overall medication satisfaction

Comparison of SF-12v2 Physical/Mental Health Scores by Subgroups to Total Population Score 7 ‡ OTC/Herbal Products  Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. General Health - summary scores. Letters indicate statistically significant 95% confidence level between subgroups Physical Health SummaryMental Health Summary Spain Total Population Score Mean=48.4 Total Spain Adults (35.4 M; n=5,039) Experiencing Pain (in the past month)* (6.1 M; n=868) Severe (C) (714 K; n=100) Mild (E) (1.5 M; n=214) Moderate (D) (3.9 M; n=554) Experiencing Pain (in the past month)* Rx (L) (551 K; n=77) OTC ‡ Only (M) (549 K; n=81) Untreated (N) (374 K; n=56) Severe: Spain Total Population Score Mean=47.4 C Rx (F) (572 K; n=81) OTC ‡ Only (G) (73 K; n=10  ) Untreated (H) (68 K; n=9  ) Rx (I) (2.6 M; n=357) OTC ‡ Only (J) (710 K; n=106) Untreated (K) (622 K; n=91) Moderate: Mild: CD I I L C

8 Pain Interfered With Normal Work During The Past 4 Weeks Total Spain Adults Exp. Pain (in the past month)* Experiencing Pain (in the past month)*SevereModerateMild Severe (C) Moderate (D) Mild (E) Rx (F) OTC ‡ Only (G) Untr- eated (H) Rx (I) OTC ‡ Only (J) Untr- eated (K) Rx (L) OTC ‡ Only (M) Untr- eated (N) 35.4 M6.1 M714 K3.9 M1.5 M572 K73 K68 K2.6 M710 K622 K551 K549 K374 K (n=5,039)(n=868)(n=100)(n=554)(n=214)(n=81)(n=10  )(n=9  )(n=357)(n=106)(n=91)(n=77)(n=81)(n=56) General Health Extremely 2%6%35% DE 2%0%34%30%53%3%2%-1%-- Quite a bit 8%23%48% DE 26% E 4%52%34%26%32% JK 15% 5%4%2% Moderately 17%27%13%31% CE 22%11%27%11%32%27%31%28%16%19% A little bit 32%36%4%34% C 58% CD 3%9%10%30%40%42% I 57%61%56% No at all 42%8%-7%16% D ---3%16% I 11% I 9%19%23% L Pain Interfered With Normal Work During The Past 4 Weeks ‡ OTC/Herbal Products  Caution: extremely small base size Zero % implies a very small value less than 0.5% *Excludes dental problems, headache, menstrual pain or migraine only. GH25: During the past 4 weeks, how much did pain interfere with your normal work (including both work outside the home and housework)? (1-5 Scale: 1=Excellent and 5=No at all) Letters indicate statistically significant 95% confidence level between subgroups

9 Physical Health Or Emotional Problems Interfered With Social Activities During The Past 4 Weeks Total Spain Adults Exp. Pain (in the past month)* Experiencing Pain (in the past month)*SevereModerateMild Severe (C) Moderate (D) Mild (E) Rx (F) OTC ‡ Only (G) Untr- eated (H) Rx (I) OTC ‡ Only (J) Untr- eated (K) Rx (L) OTC ‡ Only (M) Untr- eated (N) 35.4 M6.1 M714 K3.9 M1.5 M572 K73 K68 K2.6 M710 K622 K551 K549 K374 K (n=5,039)(n=868)(n=100)(n=554)(n=214)(n=81)(n=10  )(n=9  )(n=357)(n=106)(n=91)(n=77)(n=81)(n=56) General Health All of the time 2%4%24% DE 2%1%27%8%11%3%-1%-3%- Most of the time 8%13%29% DE 12% E 7%30%27%18%14%8%10% 5%7% Some of the time 19%27%28%29%22%26%38%28%34% JK 23%16%22%20%26% A little of a time 30% 13%31% C 36% C 14%17%-28%34%42% I 42%38%25% None of the time 41%25%7%24% C 33% CD 3%9%42%20%35% I 32% I 26%34%42% Physical Health Or Emotional Problems Interfered With Social Activities During The Past 4 Weeks ‡ OTC/Herbal Products  Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. GH35: During the past 4 weeks, how much of the time has your physical health or emotional problems interfered with your social activities (like visiting friends, relatives, etc.)? (1-5 Scale: 1=all of the time and 5=None of the time) Letters indicate statistically significant 95% confidence level between subgroups

10 ‡ OTC/Herbal Products^Differing base size  Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. All the figures are for presently Full Time employees apart from activity impairment DE30: What is your employment status? WPPCTWRK: Percentage work time missed due to health.WPIMPAIR: Percentage impairment while working due to health. WPWRKIMP: Percentage overall work impairment due to health. WPACTIMP: Percentage activity impairment due to health. (0-10 Scale: 0=health problems had no effect on my work and 10=health problems completely prevented me from working) Letters indicate statistically significant 95% confidence level between subgroups Spain Adult Work Productivity and Activity Impairment Total Spain Adults Exp. Pain (in the past month)* Experiencing Pain (in the past month)*SevereModerateMild Severe (C) Moderate (D) Mild (E) Rx (F) OTC ‡ Only (G) Untr- eated (H) Rx (I) OTC ‡ Only (J) Untr- eated (K) Rx (L) OTC ‡ Only (M) Untr- eated (N) 35.4 M6.1 M714 K3.9 M1.5 M572 K73 K68 K2.6 M710 K622 K551 K549 K374 K (n=5,039)(n=868)(n=100)(n=554)(n=214)(n=81)(n=10  )(n=9  )(n=357)(n=106)(n=91)(n=77)(n=81)(n=56) Employed full time 37%34%20%33% C 45% CD 25%--29%43% I 37%41%50%44% Absenteeism^ % work time missed due to health – past 7 days (mean) DE J Presenteeism^ % impairment while working due to health (mean) Work Productivity Loss^ % overall work impairment due to health (mean) DE J Activity Impairment % activity impairment due to health (mean) DE 41.6 E JK J 30.6 N Spain Adult Work Productivity and Activity Impairment

Type of Pain Conditions 11 *Excludes dental problems, headache, menstrual pain or migraine only. PN15: Please indicate which of the following conditions have caused you to feel pain in the past month. Letters indicate statistically significant 95% confidence level between subgroups Pain population, prevalence of conditions causing pain by pain severity (Respondents with pain in the past month) Experience Pain (in the past month) * (6.1 M; n=868) Moderate (D) (3.9 M; n=554) Mild (E) (1.5 M; n=214) Experiencing Pain (in the past month) * Back pain Headache Shoulder pain/stiffness Arthritis pain Neck pain Migraine Dental pain Sprains or strains Surgery or medical procedure Joint pain Severe (C) (714 K; n=100)

12 Experience Symptoms/Side Effects – Among Rx Opioid Users (Respondents with pain in the past month (qualified respondents), taking opioid medications, experiencing symptoms) Nausea Experience Pain (in the past month)* (239 K; n=37) Severe (C) (77 K; n=12 †† ) Moderate (D) (149 K; n=23 † ) Mild (E) (13 K; n=2 †† ) Experiencing Pain (in the past month)* Abdominal pain / discomfort Dizziness Constipation Sleepiness Trouble thinking clearly Other digestive symptoms Vomiting Feeling moody, irritable, anxious, or restless Diarrhea Bloating Other None of above Caution: † small base size; †† extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. PN60: Please indicate the symptoms you experience while taking for your pain? No statistically significant 95% confidence level between subgroups NA

13 CONTACT INFORMATION  Global Headquarters Kantar Health Health Sciences Practice 1 Independence Way, Suite 220, Princeton, NJ Telephone: +1 (609) Fax: +1 (609) Madison Avenue, 12th Floor, New York, NY Telephone: +1 (212) Fax: +1 (212) Spain NHWS 2010 Data  When referencing data from this report please use the following citation: +Kantar Health. September NATIONAL HEALTH AND WELLNESS SURVEY, 2010 [Spain]. Princeton, NJ.