E.RICHTER DEPARTMENT OF RHEUMATOLOGY UNIVERSITY OF STELLENBOSCH Immunology
Innate and adaptive immunity: cells
Innate and adaptive immunity
MHC class I and II
Complement system
Activation of innate immunity
PAMP’s and PRR
Inflammasomes
Jak Stat pathway
Cytokines
Important cytokines: TNF-alfa
Interleukin-6
Interleukin-6 and the liver
Adaptive immunity: T cell development Positive selection: selection of T cells capable of interacting with MHC molecules. If does not bind to MHC apoptosis. Develops into either CD4 or CD8 depending on if it binds MHC class I or II. Negative selection: presented with MHC bound to self Ag. If binds too strongly apoptosis.
Requires both signals in order to activate. CD 28 expressed on all CD4 and 50% of CD8 CTLA-4 negative regulator of T cells. Only transiently expressed after T cell activation. Activation of T cell
T-helper cells: subsets
Adaptive immunity: B cells development
B cells: activation
Immunoglobulin's
Autoimmunity Black arrows=normal events in T cell development Red arrows = circumstances disrupting events autoimmunity
Autoimmunity
Autoimmunity: superantigen