By, Acchaya Bajracharya & Veronika Putzenlechner

 HPV = Human Papilloma Virus  More than 170 types of HPV  Transferred via skin on skin contact  Can lead to cancer  Some types show symptoms, others do not

 Non-enveloped DNA Virus  Family: Papillomavirus family  Establish only on basal keratinocytes of skin/mucous membrane  HPV types 6 and 11: cause genital warts  HPV types 16 and 18: may progress to precancerous lesions and invasive cancer

 generally skin contact:  perinatal  genital infections  hands  shared objects (toys)  blood  surgery

 Cancer  Respiratory papillomatosis  Immuno-comprimised  Genital wart  Skin warts  Types of warts:  Common skin warts  plantar warts  subungual or periungual warts  flat warts

Incidence of HPV associated cancers in USA ( )

 Estimated global prevalence = 11.7% (women)  Sub-Saharan Africa = 24%  Eastern Europe = 21.4%  Latin America = 16.1% Highest percentage of cases of HPV in women

Estimated deaths since 2014: Worldwide = United States = 11139

 Vaccine:  Gardasil  Gardasil 9  Cervarix  Education  Social mobilization  Screening  Papillative care  Use & promotion of safe sex – condoms  Male circumcision Protection against HPV types: 6, 11, 16 & 18 Protection against HPV types: 16 & 18

 Currently no specific treatment for HPV  Virus normally clears by itself – within 2 years  Genital warts:  Physical ablation – e.g. Excision, cryosurgery, etc.  Topical agents – e.g. 0.15–0.5% podophyllotoxin solution  Cancer:  chemotherapy

 DRACO drug = early stages  Alferon N = drug to treat genital warts  Lopinavir = antiretroviral – of the protease inhibitor class

    prevention/risk/infectious-agents/hpv-fact-sheet#q4 prevention/risk/infectious-agents/hpv-fact-sheet#q4    org/wiki/Papillomaviridae org/wiki/Papillomaviridae  