Bio 328 Immunology Cancer and the Immune System.

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Presentation transcript:

Bio 328 Immunology Cancer and the Immune System

Human carcinogens: 1.Chemicals (mutagens) 2.Irradiation (UV,  -ray) 3.Viruses: a)Human T cell Leukemia Virus b)Human Herpes Virus 8 c)Human Papilloma Virus d)Epstein-Bar Virus e)Hepatitis B virus

Tasmanian Devil (Sarcophilus harisii)

Transmissible facial tumor.

Canine Transmissible Venereal Tumor:

EGF receptor oncogenes (1)Overexpression of Her2 (human) (2)Mutation of valine to glutamine in transmembrane domain: constitutively active (human) (3)Loss of extracellular domain: constitutively active (mice.)

Dr. Janet D. Rowley and Dr. Timothy McKeithan (1973)

Dr. JD Rowley has received numerous awards and honors, including most recently the Presidential Medal of Freedom from Pres. B. Obama

Translocation (9, 22) creates the fusion protein of BCR (function unknown) and Abl (cytoplasmic protein kinase regulating actin polumerization). BCR-Abl is a protein kinase with broad target specificity including JAK 2 and STAT5.

Imatinib (GLEEVEC) is specific inhibitor of BCR-Abl and is approved for treatment of Chronic Myelogenous Leukemia.

William Coley (centre) was the first to practise cancer immunotherapy in 1890.

Serratia marcescens (prodigiosin) Streptococcus pyogenes Coley vaccine:

ProVenge.

ProVenge

Immunologist Karolina Palucka, at the Baylor Institute for Immunology Research in Dallas, Texas, helped treat Nobel prizewinner Ralph Steinman's pancreatic cancer with dendritic cells — the cells he co-discovered. Here she explains the use of dendritic cells in cancer immunotherapy.

CTL attacking a cancer cell.

President Carter annmounces he is melanoma free after treatment with OPDIO and Ipilumab. (Estimated cost: $150,000

CAR T cell therapy. scFv = Single-chain Fv

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Wu Chia-Yung et al. Science 16 October 2015 vol 350 p293.

The End