OVARIAN CYCLE.

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Presentation transcript:

OVARIAN CYCLE

SECTION OF OVARY

Females undergo regular monthly reproductive/sexual cycles commencing at puberty. Ovarian cycle Menstrual cycle

These sexual cycles involves the activity of: Hypothalamus Pituitary gland Ovary Uterus Uterine tubes Vagina Mammary glands Function: To prepare the reproductive system for pregnancy

No effect on growth of primordial follicle OVARIAN CYCLE No effect on growth of primordial follicle to primary follicle 15-20 primary follicles Atretic Corpus atreticum

Functions: FSH ESTROGENS Necessary for the growth of primary, secondary & tertiary follicles Stimulates maturation of granulosa cells (GDF9) Estrogens is Produced by: theca interna cells anderostendione + testosterone granulosa cells convert them into estrone & 17B-estradiol. ESTROGENS Prepares the uterine endometrium to enter into proliferative phase Thinning of cervical mucus Stimulates the pituitary gland to secrete LH

Cont… PROGESTERONE LH Surge Brings secretory changes in the uterine endometrium Prepares the uterus for implantation of embryo LH Surge Elevates the concentration of MPF causing oocyte to complete Meiosis I and initiate Meiosis II. Stimulates production of Progesterone by the follicular cells (luteinization) Causing follicular rupture & ovulation Arrested in metaphase When secondary follicle is mature, LH surge induces a preovulatory growth phase

OVULATION (Release of secondary oocyte) Prior to ovulation secondary follicle grows rapidly (25mm) under influence of FSH & LH At the same time abrupt increase in LH causes Meiosis I to complete and follicle to enter preovulatory stage, Meiosis II initiated and arrested in metaphase 3hrs prior to ovulation

Cont… Increase in volume & pressure of follicular fluid Overlying ovarian cortex become thin & translucent Surface of ovary bulge locally: stigma formation High concentration of LH, increased collegenase activity that digests collagen fibers around follicle and increased PG levels increases muscular contractions of ovarian wall Oocyte along with granulosa cells break free (ovulation) . Rearrangement of cumulus oophorus cells around ZP forms corona radiata.

OVULATION Surgeons who were performing hysterectomy witnessed spontaneous ovulation and were lucky to record it. Ovulation was not an explosive event as it is assumed but rather a 15 min long and smooth release of an egg.

OVULATION SYMPTOMS Middle pain (Mittelschmerz): Rise in basal body temperature

Corpus Luteum (LH) After ovulation, Follicle collapses Granulosa and theca interna cells hypertrophy, leutenized & vasularized Secretes Progesterone some estrogens. Causes uterine mucosa to enter into progestational phase.

OOCYTE TRANSPORT Sweeping movements of fimbriae Rhythmic muscular contractions of tube Motion of cilia in tubal mucosa Fluid currents Fertilized oocyte reaches uterine lumen in 3-4 days

Corpus albicans (Absence of HCG)  Latin for "whitening body“ is the regressed form of the corpus luteum. As the corpus luteum is being broken down by macrophages, fibroblasts lay down type I collagen forming the corpus albicans. The remains of the corpus albicans may persist as a scar on the surface of the ovary.

Thank you