1 WIDE-FIELD AND HIGH-RESOLUTION OPTICAL IMAGING FOR EARLY DETECTION OF ORAL NEOPLASIA Professor: WANG,CHI-JO Student: CHEN,CHING-YUAN 1 Proc. of SPIE Vol.7548 Mark C. Pierce, Richard A. Schwarz, Kelsey Rosbach, Darren Roblyer, Tim Muldoon, Michelle D. Williams, Adel K. El-Naggar, Ann M. Gillenwater, Rebecca Richards- Kortum PPT 製作率 :100 ％

2 Outline  Introduction  Wide-field imaging  High-resolution microendoscopy  Conclusions 2

3 Introduction (1/7)  Oral cancer is the 11th most common cancer worldwide, with an estimated 35,000 new cases and 7,500 deaths due to the disease in the US in  Current procedures for oral cancer screening typically involve visual inspection of the entire tissue surface at risk under white light illumination. 3

4 Introduction (2/7)

5 Introduction (3/7) 5-year survival rates 5

6 Introduction (4/7)  pre-cancerous lesions can be difficult to distinguish from many benign conditions when viewed under these conditions.  However, visual identification of oral lesions can be challenging even for specialized clinicians, with the task made even harder for less experienced healthcare providers. 6

7 Introduction (5/7)

8 Introduction (6/7)

9 Introduction (7/7)  This paper has developed both wide-field and high-resolution optical imaging devices for cancer detection, evaluating large scale prototypes in US-based clinical studies. 9

10 Wide-field imaging (1/2) 10

11 Wide-field imaging (2/2) 11

12 High-resolution microendoscopy(1/2) 12

13 High-resolution microendoscopy(2/2) 13

14 Conclusions  We have demonstrated the ability of these systems to detect relevant biochemical and morphological indicators of disease in oral mucosa, namely stromal collagen auto-fluorescence, and epithelial call morphology.  Both wide-field and high-resolution systems have been assembled for under $4000 each, and are currently under evaluation in pilot clinical studies. 14

15 Thank You! 15