ISGO International Conference on Structural Genomics Looking back to the committee’s earlier report … Berlin, October 2002 Task force on tracking and registration of targets

Report of Structural Genomics Task Force on Target Tracking Steve Bryant Steve Brenner Yo Matsuo John Moult Janet Thornton April 4-6, 2001, Airlie House

Airlie House Recommendations... Structural Genomics Laboratories shall adopt a policy of open exchange of target information … … to facilitate target selection and avoid unnecessary duplication of effort … to demonstrate international cooperation in the structural genomics effort

Airlie House Recommendations... Data exchange shall be by the simplest possible method … … each laboratory shall maintain a public ftp site listing target sequences and the status of experimental work … in a simple standardized format to be finalized by a working group the Airlie House meeting

Summary of discussion on target data-exchange format Information content … … laboratory-assigned target name … laboratory name … date of most recent update … target sequence … status-of-work code

Summary of discussion on target data-exchange format Status-of-work code examples … … cloned … purified … crystallized … in PDB … work stopped

Target registry XML format...

Summary of discussion on target data-exchange mechanisms Three options were considered … … a “deluxe” central registry … a “bare bones” central registry … a decentralized registry, where each laboratory independently maintains a list of targets under investigation

The “bare bones” target registry...

Airlie House Recommendations... The need for a central target registry should be considered again in future … … laboratories may evaluate the registry to be developed by John Norvell for the NIH-funded centers … if this proves to be more efficient means of data exchange, an international repository should be created in future

Now that this has been done, questions for discussion today... Does the “bare bones” central target registry achieve its goals ? … to avoid duplication … to demonstrate cooperation Should additional information be included in the central target registry ? … target synonyms ? … target classification ? … other suggested targets ?