Delivering clinical research to make patients, and the NHS, better Colorectal SSG March 2015 Research Wendy Cook, Research Delivery Manager dd/mm/yyyy

Cover Overview of network changes Overview of research activity Discussion re new studies for the portfolio 2 r

History April 2013 Cancer Network dissolved SSG’s in the main stopped in Peninsula Network Historically Peninsula Cancer Research Network RD&E, N Devon, S Devon, Plymouth and RCHT 1 of 32 Cancer networks Peninsula, a very successful network Governed by the NCRN (National cancer research Network) April 2014 Research Transition

Transition 15 Local Research Networks, Nationally. I LRN has 30 specialties Geographical changes Area now includes Musgrove Park and Yeovil New name CRN: South West Peninsula (Local Research Network) Local governance 1 funding stream Funding given to Trusts in 1 block, not broken down into cancer, diabetes, stroke etc 4

South West Peninsula CRN HospitalSize Yeovil District Hospital NHS Foundation Trust Small Acute Taunton and Somerset NHS Foundation Trust Medium Acute Northern Devon Healthcare NHS Trust Small Acute Royal Devon and Exeter NHS Foundation Trust Large Acute South Devon Healthcare NHS Foundation Trust Medium Acute Plymouth Hospitals NHS TrustLarge Acute Royal Cornwall Hospitals NHS TrustLarge Acute

Structure 6

Management of Division Performance Management and portfolio development LPMS (EdGE) RAG review FPFV and T2T Tracking of EOI return rates Identification of new studies and promotion Level 1 and level 2 studies, commercial and non commercial Identify blocks and escalate e.g. ETC’s, supporting services Coordinate regional team meetings/forums, workshops, share good practice, work collaboratively Attend national cancer research meetings Attend SSG’s Providing recruitment data and trials information to the SSG Support Peer Review 7

Recruitment TrustStudyCSG2013/ /2015Total Plymouth Hospitals NHS TrustCReSTColorectal Cancer Group 25 Plymouth Hospitals NHS TrustPulmonary Metastasectomy in Colorectal Cancer (PulMICC)Colorectal Cancer Group6314 Royal Cornwall Hospitals NHS TrustMARVELColorectal Cancer Group 99 Royal Cornwall Hospitals NHS TrustNSCCGColorectal Cancer Group 1244 Royal Devon and Exeter NHS Foundation TrustAristotleColorectal Cancer Group 34 Royal Devon and Exeter NHS Foundation TrustCORGIColorectal Cancer Group Royal Devon and Exeter NHS Foundation TrustDoes aspirin increase the clinical response to chemo-radiotherapy?Colorectal Cancer Group 77 Royal Devon and Exeter NHS Foundation TrustNSCCGColorectal Cancer Group 1325 South Devon Healthcare NHS Foundation TrustROLARR (RObotic versus LAparoscopic Resection for Rectal cancer)Colorectal Cancer Group3213 South Devon Healthcare NHS Foundation TrustThe impact of robotic surgery on teamwork (v1)Colorectal Cancer Group 22 Taunton and Somerset NHS Foundation TrustFOCUS-4: Molecular selection of therapy in colorectal cancerColorectal Cancer Group 11 Taunton and Somerset NHS Foundation TrustFOxTROTColorectal Cancer Group218 Taunton and Somerset NHS Foundation TrustNSCCGColorectal Cancer Group 1130 Taunton and Somerset NHS Foundation TrustSTARRCAT Trial: Surgical Timing After Radiotherapy for Rectal CancerColorectal Cancer Group314 Yeovil District Hospital NHS Foundation TrustAristotleColorectal Cancer Group 11 8

Historical recruitment Trust Pre 2008/ /092009/102010/112011/122012/ /142014/15Total N Devon Plym RCHT RD&E S Devon Taunton Yeovil

Focus 4 - Issues Open for 12 months. 46/100 sites are open. Not all Level 3 sites are open. This is a priority with the Trial Centre Training on electronic data has been an issue, delaying set up at sites. Capacity issues at the TC which are currently being addressed. Sites are finding the CT schedule very tight, which leads to patients being excluded. 10

cont Trial management team are looking at the platelet count inc/ex re evidence. There may be a possibility that this may be amended. Changing site study Level - Site level was determined by the information sites submitted to the TC. If a site does not agree with their Level (of treatment) this can be discussed with the TC and levels can be changed but there needs to be dialogue between site and TC. 11

Division 1 Duncan Wheatley, Clinical Specialty Lead Wendy Cook, Research Delivery Manager Ann Courtman, Administrator Subspecialty leads Nader Francis 12

An invite to Cancer Research Symposium From Clinical Trials to Clinical Practice Hosted by RD&E Jenny Forrest & Kate Scatchard, Consultant Clinical Oncologists at Gipsy Hill Hotel, Exeter Friday 15 th May 2015 Contact for more information