Fellow, Dept of Hematopathology 1515 Holcombe Blvd, Unit 072

Slides:

Advertisements

Similar presentations

Approach to Acute Leukemia

Advertisements

MALIGNANCIES OF THE HAEMAPOIETIC STEM CELL. Haemapoietic Stem Cell are pluripotent and give rise to all of the haemopoietic cell under the action of cytokines.

Coding Haematological Malignancies in Cancer Registries part I : Myeloid malignancies Pr Marc Maynadié Registre des Hémopathies Malignes de Côte d'Or Faculté.

A Hematology Case Study about Leukemia by Sarah Wycoff

ECSI case Fall 2014 Andrea M. Sheehan, MD Associate Professor of Pathology & Immunology Baylor College of Medicine.

Tabuk University Faculty of Applied Medical Sciences

NYU Medicine Grand Rounds Clinical Vignette Maryann Kwa, MD PGY-2 January 12, 2011 U NITED S TATES D EPARTMENT OF V ETERANS A FFAIRS.

Kentucky Cancer Registry Spring training, 2010 H EMATOPOIETIC AND L YMPHOID N EOPLASM P ROJECT.

Myeloprolifrative disorders -Chronic Myelogenouse Leukemia - Primary Poly Cythemia ( vira ) - Essential Thrombocythemia - Myelofibrose Myeloid Methaplasia.

Acute Leukemia and the FLT3 Receptor B y: Betty Sa’ Mentor: Dr. Govind Bhagat Site: Columbia University Vanderbilt Clinic.

Pei Lin, MD Department of Hematopathology UT M.D. Anderson Cancer Center, Houston, TX Monitoring of Minimal Residual Disease Principles and Applications.

Case Study MICR Hematology Spring, 2011 Case # 6 Monique Quiroz Mike Pehl Andrew Ho.

Acute Myeloid Leukemias Diagnosis in The Light of WHO Revisions And Correlation With Risk Adaptive Management ; Case Discussions Dr. Rania Medhat Seliem.

Chronic Leukemias. CMLCML CLLCLL CML A clonal disease results from an acquired genetic change in a pluri-potential hemopoietic stem cell within the BM.

ICCS e-Newsletter CSI Fall 2010 David D. Grier, M.D. Department of Pathology. Wake Forest University.

Role of Immunoglobulin Gene Expression in Acute Myeloid Leukemia C. Cameron Yin, MD, PhD Department of Hematopathology University of Texas MD Anderson.

Pei Lin Professor of Pathology Department of Hematopathology

ZHIHONG HU, MD, PhD Fellow, Department of Hematopahtology

The Dual E-selectin/CXCR4 Inhibitor, GMI-1359, Enhances Efficacy of Chemotherapy in FLT3-ITD-Mutated Acute Myeloid Leukemia Weiguo Zhang 1, Nalini B Patel.

Good morning… My presentation is about Calreticulin and PMF

Case Presentation 31 year-old man with increased blast count

Single-Agent Lenalidomide Induces Complete Remission of Acute Myeloid Leukemia in Patients with Isolated Trisomy 13 Fehniger TA et al. Blood 2009;113(5):

DEBBIE A. MCKNIGHT.  Examine the cells microscopically for color, size, shape, structure and pattern for disease and treatment of illness.  Process.

B-ALL as the Initial Presentation of a Hematopoietic Neoplasm with t(8;22)/BCR-FGFR1 The University of Texas MD Anderson Cancer Center Department of Hematopathology.

Acute Leukemia Kristine Krafts, M.D..

ICCS e-Newsletter CSI Hamid Zia, MD Andrew Chu, MD Franklin Fuda, DO Department of Pathology University of Texas Southwestern Medical Center Dallas, Texas.

Chapter 12 The diseases of Hematopoietic and Lymphoid System Liu weiping Department of Pathology West China School of Medicine Sichuan University.

Case report Sudden blastic transformation in patient with chronic myeloid leukemia treated with imatinib mesylate Mehrdad Payandeh,MD Hematology, Medical.

Case 297 Guilin Tang and Sa A. Wang Department of Hematopathology UT MD Anderson Cancer Center.

C ASE S TUDIES IN N EUROPATHOLOGY Kenneth Clark, MD Neuropathology Fellow, UPMC.

Case 251: Clinical Information Raymond E Felgar, MD, PhD University of Pittsburgh, Pittsburgh, PA 45-year-old man with recent history of shingles, night.

LEUKEMIA Dr. Omar Alshaer. Acute Leukemia.

Case 255 Elizabeth Courville, MD Robert Hasserjian, MD Massachusetts General Hospital Society for Hematopathology/European Association for Haematopathology.

AML Clinical Presentation. Clinical Presentation: Symptoms Fatigue (50%) Anorexia and weight loss Fever with or without an identifiable infection (10%)

Case 398 Submitting Author: Hutchison, Robert E, MD Institution: SUNY Upstate Medical University Additional authors: Constance K. Stein, Ph.D., Theresa.

Society for Hematopathology/European Association for Haematopathology 2013 Case Number 208 Erika Moore, MD; Darshan Roy, MD; Patti Cohen, MD; Adam Bagg,

SH/EAHP Workshop 2013 Case 93 Winnie Wu, M.D. Sheeja Pullarkat, M.D.

Case 324 SH/EAH Workshop - Huston TX, October 2013 Leonardo Boiocchi, M.D. & Attilio Orazi, M.D. Weil Cornell Medical College, New York, NY Università.

Society for Hematopathology/ European Association for Haematopathology Case 211 Rachel Ochs, MD Adam Bagg, MD Hospital of the University of Pennsylvania.

Case 316 Ryan Johnson, MD; Athena Cherry, PhD; Dita Gratzinger, MD, PhD Stanford University Medical Center SH-EAHP October 24, 2013.

CASE 411 Jose Gonzalez-Berjon, MD & Tariq Muzzafar, MD UT M.D. Anderson Cancer Center.

CP Case Conference Aplastic Anemia 1/27/12 Laura Walters.

ICCS e-Newsletter CSI Fall 2015 Hywyn R. O. Churchill, MD PhD Division of Hematopathology.

Patient history 70 year-old male with macrocytic anemia for 10 years, became transfusion dependent. Splenectomy for refractory anemia: 670gm B12, folate,

Acute Leukemia Kristine Krafts, M.D..

Brief pain inventory. (Reproduced with permission from the University of Texas MD Anderson Cancer Center, Department of Symptom Research, Houston, TX.

Session 7, case 171 Extramedullary Manifestations of Myeloid Neoplasms

EAHP Bone Marrow Workshop

eCSI case 2 – November 2016 Jyotinder Nain Punia, MD

CASE SUBMISSION 2016 EAHP BM Workshop

Clinical history 30-years-old female

Julia Geyer and Attilio Orazi

AML Blast Cells. Wright stained peripheral blood smear, ×1000

Evaluating Quality in Clinical Cancer Research: The M. D

Department of Hematopathology

University of Vermont Medical Center

Biology of MDS/MPN overlap syndromes (except CMML)

Case Study ….

Case:2 leukemia دينا نعمان جرادة جيهان ايمن مقاط.

Header Supplemental Questions to Malignant Peripheral Blood and Bone Marrow Review Mark D. Fleming, M.D., D.Phil. Subhead.

Diagnostic Hematology

by Tahereh Dadfarnia, and Stephen Lee

A presentation By Abedelaziz Taha Hammash supervisor \ Mr

A New Therapeutic Target for Leukemia Comes to the Surface

Ayalew Tefferi, MD Mayo Clinic Proceedings

Chronic Leukemia Dr. Noha Noufal.

Clinical, molecular, and immunological responses to pembrolizumab treatment of synchronous melanoma and acute myeloid leukemia by Anne Sophie Kubasch,

Timing for HCT Consultation

Casual finding in the Laboratory of Chronic Myeloid Leukemia Falcones,K; Ortega,JJ; Ricart,E; Molina,R Hospital Virgen de los Lirios de Alcoy INTRODUCTION:

In vivo efficacy of JAK inhibition in transformed Pax5+/− pro-B cells harboring Jak3V670A. In vivo efficacy of JAK inhibition in transformed Pax5+/− pro-B.

Presentation transcript:

Fellow, Dept of Hematopathology 1515 Holcombe Blvd, Unit 072 Huifei Liu, MD, PhD Fellow, Dept of Hematopathology 1515 Holcombe Blvd, Unit 072 The University of Texas at MD Anderson Cancer Center Houston, TX 77030

Clinical History 71-year-old man Anemia for several months with recent progressive shortness of breath PMH: asthma, hypertension, BPH, hyperlipidemia Testosterone supplement since 4/2013 Splenomegaly

PB: Blasts (18%) with eosinophilia (29%) and Anemia

PB: Atypical eosinophil

BM: 30% Blasts with 15% eosinophils

BM: ↑Immature Cells, Eosinophils, Megakaryocytyes

BM: Megakaryocytic Hyperplasia/Dysplasia

Flow Cytometry

Flow Cytometry

Immunophenotype of Blasts CD34+/CD117+/CD45+ CD13+/CD33+/CD38+/HLADR+ CD4dim/CD5dim/CD7p+/CD25p+/CD56+ MPO− CD2−/CD3−/CD10−/CD14−/CD15− CD19−/CD123−/TdT−

Cytogenetics & Molecular Diagnostics 45,XY,-7[20] FLT3 ITD ASXL1 PTPN11 PDGFRA rearrangement (-) PDGFRB rearrangement (-) BCR/ABL1 (-) CHIC2 deletion (-)

Diagnosis ACUTE MYELOID LEUKEMIA WITH FLT3-ITD MUTATION IN A BACKGROUND OF MARKED EOSINOPHILIA AND MARKED MEGAKARYOCYTIC HYPERPLASIA

Discussion 1+1=? 1+1+1=? 1+1+1+……=? How does multiple mutations interact to shape clinical presentation and treatment responses? 1+1=? 1+1+1=? 1+1+1+……=?